644970-36-5

Basic information

• Product Name: tert-butyl 3-hydroxy-3-(trifluoroMethyl)pyrrolidine-1-carboxylate
• Synonyms: tert-butyl 3-hydroxy-3-(trifluoroMethyl)pyrrolidine-1-carboxylate
• CAS NO: 644970-36-5
• Molecular Formula: C10H16F3NO3
• Molecular Weight: 255.2341496
• EINECS: -0
• Mol File: 644970-36-5.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: tert-butyl 3-hydroxy-3-(trifluoroMethyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-hydroxy-3-(trifluoroMethyl)pyrrolidine-1-carboxylate(644970-36-5)
• EPA Substance Registry System: tert-butyl 3-hydroxy-3-(trifluoroMethyl)pyrrolidine-1-carboxylate(644970-36-5)

Safety Data

• Hazardous Substances Data: 644970-36-5(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis Industry:
Tert-butyl 3-hydroxy-3-(trifluoromethyl)pyrrolidine-1-carboxylate is used as a synthetic intermediate for the production of complex molecules, leveraging its unique trifluoromethyl group to facilitate the synthesis process and enhance the properties of the resulting compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, tert-butyl 3-hydroxy-3-(trifluoromethyl)pyrrolidine-1-carboxylate is used as a key building block in the development of new drugs, particularly those targeting specific biological pathways or requiring enhanced bioavailability and stability due to the presence of the trifluoromethyl group.
Used in Agrochemical Industry:
Tert-butyl 3-hydroxy-3-(trifluoromethyl)pyrrolidine-1-carboxylate is employed as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides, where its unique structure can contribute to the effectiveness and selectivity of these compounds in controlling pests and unwanted plant growth.
Used in Material Science:
In the field of material science, tert-butyl 3-hydroxy-3-(trifluoromethyl)pyrrolidine-1-carboxylate is utilized in the development of novel materials with specific properties, such as improved thermal stability, chemical resistance, or tailored surface characteristics,得益于其独特的化学结构和三氟甲基团。

Upstream product

• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 1445804-37-4 3-(2-carboxy-phenoxy)-3-trifluoromethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1445804-36-3 3-(2-formyl-phenoxy)-3-trifluoromethylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 196822-27-2 (3RS)-3-(trifluoromethyl)pyrrolidin-3-ol 
• 644970-40-1 tert-butyl 3-(trifluoromethyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Heterocyclic IDH mutant inhibitor, preparation method and application thereof

The invention discloses a heterocyclic IDH mutant inhibitor, a preparation method and application thereof, belongs to the field of medicines, and particularly relates to a s-triazine compound with structural characteristics of a general formula (I) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition, a preparation method of the s-triazine compound, and application of the s-triazine compound or the pharmaceutically acceptable salt and the pharmaceutical composition as isocitrate dehydrogenase 2 (IDH2) mutant inhibitors. The compound disclosed by the invention has an obvious inhibiting effect on the activity of an IDH2 mutant (mIDH2), can effectively inhibit the process of catalyzing alpha-ketoglutaric acid to generate 2-hydroxyglutaric acid by the mIDH2, and can be used for preventing and/or treating various related diseases including cancers caused by IDH2 mutation.

4 -Aminopyridine derivative, pharmaceutical composition, preparation method and application thereof

The invention discloses a 4-aminopyridine derivative, a preparation method, a pharmaceutical composition and application thereof. The 4-aminopyridine derivative (I), an isomer, a prodrug, a stable isotope derivative or a pharmaceutically acceptable salt thereof have the following structure shown in the specification. The 4-aminopyridine derivative has a good adenosine A2a receptor antagonist effect, and related diseases such as cancer, central nervous system diseases and the like caused by adenosine A2a receptor level disorder can be effectively treated or relieved.

HETEROCYCLIC COMPOUND

Provided is a compound useful for the prophylaxis or treatment of cancer. The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.

NOVEL TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES

The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, Z, R3, R4, R5, R6, R7, R8, t and R9 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.