3-{[(3-Fluorobenzyl)oxy]methyl}-1-methyl-4,5,6,7-t etrahydro-1H-pyrazolo[4,3-c]pyridine hydrochlorid

Base Information

• Chemical Name: 3-{[(3-Fluorobenzyl)oxy]methyl}-1-methyl-4,5,6,7-t etrahydro-1H-pyrazolo[4,3-c]pyridine hydrochlorid
• CAS No.: 1332529-63-1
• Molecular Formula: C₁₅H₁₈FN₃O*ClH
• Molecular Weight: 311.787
• Mol file: 1332529-63-1.mol

Synonyms:

Chemical Property of 3-{[(3-Fluorobenzyl)oxy]methyl}-1-methyl-4,5,6,7-t etrahydro-1H-pyrazolo[4,3-c]pyridine hydrochlorid

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

3-{[(3-Fluorobenzyl)oxy]methyl}-1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{[(3-Fluorobenzyl)oxy]methyl}-1-methyl-4,5,6,7-t etrahydro-1H-pyrazolo[4,3-c]pyridine hydrochlorid

There total 4 articles about 3-{[(3-Fluorobenzyl)oxy]methyl}-1-methyl-4,5,6,7-t etrahydro-1H-pyrazolo[4,3-c]pyridine hydrochlorid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H26FN3O3 → 3‐{[(3‐fluorobenzyl)oxy]methyl}‐1‐methyl‐4,5,6,7‐tetrahydro‐1H‐pyrazolo[4,3‐c]pyridine hydrochloride (1332529-63-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; Inert atmosphere; Sonication;

DOI:10.1002/ardp.202000275

Reference yield:

5‐tert‐butyl 3‐ethyl 1,4,6,7‐tetrahydro‐5H‐pyrazolo[4,3‐c]pyridine‐3,5‐dicarboxylate (518990-23-3) → 3‐{[(3‐fluorobenzyl)oxy]methyl}‐1‐methyl‐4,5,6,7‐tetrahydro‐1H‐pyrazolo[4,3‐c]pyridine hydrochloride (1332529-63-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / toluene / 6 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

3.2: 7 h / Inert atmosphere; Reflux

4.1: hydrogenchloride / 1,4-dioxane / Inert atmosphere; Sonication

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; 1,4-dioxane; toluene;

DOI:10.1002/ardp.202000275

Reference yield:

5-(tert-butyl) 3-ethyl 1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3,5-dicarboxylate (1142210-81-8) → 3‐{[(3‐fluorobenzyl)oxy]methyl}‐1‐methyl‐4,5,6,7‐tetrahydro‐1H‐pyrazolo[4,3‐c]pyridine hydrochloride (1332529-63-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

2.2: 7 h / Inert atmosphere; Reflux

3.1: hydrogenchloride / 1,4-dioxane / Inert atmosphere; Sonication

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1002/ardp.202000275

upstream raw materials:

5‐tert‐butyl 3‐ethyl 1,4,6,7‐tetrahydro‐5H‐pyrazolo[4,3‐c]pyridine‐3,5‐dicarboxylate

5-(tert-butyl) 3-ethyl 1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3,5-dicarboxylate