5-tert-butyl 3-ethyl 1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3,5-dicarboxylate

Base Information

• Chemical Name: 5-tert-butyl 3-ethyl 1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3,5-dicarboxylate
• CAS No.: 1142210-81-8
• Molecular Formula: C₁₅H₂₃N₃O₄
• Molecular Weight: 309.365
• Hs Code.: 2933990090
• Mol file: 1142210-81-8.mol

Synonyms:5-tert-butyl 3-ethyl 1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3,5-dicarboxylate;5H-pyrazolo[4,3-c]pyridine-3,5-dicarboxylic acid, 1,4,6,7-tetrahydro-1-methyl-, 5-(1,1-dimethylethyl) 3-ethyl ester;5-tert-butyl 3-ethyl 1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3,5-dicar

Chemical Property of 5-tert-butyl 3-ethyl 1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3,5-dicarboxylate

Chemical Property:

• Boiling Point: 458.0±45.0 °C(Predicted)
• PKA: 0.50±0.20(Predicted)
• PSA: 73.66000
• Density: 1.22±0.1 g/cm3(Predicted)
• LogP: 1.82790

Purity/Quality:

97% ^*data from raw suppliers

5-tert-Butyl3-Ethyl1-Methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3,5-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-tert-Butyl 3-Ethyl 1-Methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3,5-dicarboxylate is used as a reactant in the synthesis of pyrazolo thiazole derivatives with antifungal activities.

Technology Process of 5-tert-butyl 3-ethyl 1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3,5-dicarboxylate

There total 8 articles about 5-tert-butyl 3-ethyl 1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5‐tert‐butyl 3‐ethyl 1,4,6,7‐tetrahydro‐5H‐pyrazolo[4,3‐c]pyridine‐3,5‐dicarboxylate (518990-23-3) + methyl iodide (74-88-4) → 5-(tert-butyl) 3-ethyl 1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3,5-dicarboxylate (1142210-81-8)

Guidance literature:

With sodium hydride; In toluene; at 20 ℃; for 6h; regioselective reaction; Inert atmosphere;

DOI:10.1002/ardp.202000275

Reference yield: 57.0%

5‐tert‐butyl 3‐ethyl 1,4,6,7‐tetrahydro‐5H‐pyrazolo[4,3‐c]pyridine‐3,5‐dicarboxylate (518990-23-3) + methyl iodide (74-88-4) → 5-(tert-butyl) 3-ethyl 1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3,5-dicarboxylate (1142210-81-8) + 5-(tert-butyl) 3-ethyl 2-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3,5-dicarboxylate

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/acs.jmedchem.9b01876

Reference yield: 52.0%

tert-butyl 3-(2-ethoxy-2-oxo-acetyl)-4-oxo-piperidine-1-carboxylate (518990-24-4) + methyldiazene (22038-72-8,26981-93-1,51943-20-5) → 5-(tert-butyl) 3-ethyl 1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3,5-dicarboxylate (1142210-81-8)

Guidance literature:

In ethanol; at 0 - 20 ℃; for 48h; Reflux;

DOI:10.1016/j.bmcl.2019.07.003

upstream raw materials:

N-tert-butoxycarbonyl-4-(tetrahydropyrrole-1-yl)-1,2,3,6-tetrahydropyridine

N-tert-butyloxycarbonylpiperidin-4-one

tert-butyl 3-(2-ethoxy-2-oxo-acetyl)-4-oxo-piperidine-1-carboxylate

methyldiazene