3-(3-TRIFLUOROMETHYL-PHENOXY)-PHENYLAMINE

Base Information

• Chemical Name: 3-(3-TRIFLUOROMETHYL-PHENOXY)-PHENYLAMINE
• CAS No.: 625106-28-7
• Molecular Formula: C₁₃H₁₀F₃NO
• Molecular Weight: 253.224
• Mol file: 625106-28-7.mol

Synonyms:

Chemical Property of 3-(3-TRIFLUOROMETHYL-PHENOXY)-PHENYLAMINE

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

3-(3-trifluoromethyl-phenoxy)-phenylamine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-TRIFLUOROMETHYL-PHENOXY)-PHENYLAMINE

There total 4 articles about 3-(3-TRIFLUOROMETHYL-PHENOXY)-PHENYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

m-trifluoromethylphenyl iodide (401-81-0) + m-Hydroxyaniline (591-27-5) → 3-(3-(trifluoromethyl)phenoxy)aniline (625106-28-7)

Guidance literature:

With 2-Picolinic acid; potassium phosphate; copper(l) iodide; In dimethyl sulfoxide; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja9081815

Reference yield: 68.0%

3-bromo-1-trifluoromethylbenzene (401-78-5) + m-Hydroxyaniline (591-27-5) → 3-(3-(trifluoromethyl)phenoxy)aniline (625106-28-7)

Guidance literature:

With 2-Picolinic acid; potassium phosphate; copper(l) iodide; In dimethyl sulfoxide; at 90 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja9081815

Reference yield:

3-Trifluoromethylphenol (98-17-9) → 3-(3-(trifluoromethyl)phenoxy)aniline (625106-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 160 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen / water monomer; methanol / 4 h / 20 °C

With palladium on activated charcoal; hydrogen; potassium carbonate; In methanol; water monomer; N,N-dimethyl-formamide;

upstream raw materials:

3-bromo-1-trifluoromethylbenzene

m-Hydroxyaniline

m-trifluoromethylphenyl iodide

3-fluoro-1-nitrobenzene

Refernces

• 1、 Maiti, Debabrata,Buchwald, Stephen L.. "Orthogonal Cu- and Pd-based catalyst systems for the O- and N-arylation of aminophenols". supporting information; experimental part. p. 17423 - 17429. Retrieved 2010/03/25.