Acetic acid, (4-((2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-, (1-((4-(4-chlorophenyl)-1-piperazinyl)methyl)-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide

Base Information

Chemical Name:Acetic acid, (4-((2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-, (1-((4-(4-chlorophenyl)-1-piperazinyl)methyl)-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide
CAS No.:136603-18-4
Molecular Formula:C₄₂H₃₄ClN₇O₄
Molecular Weight:736.229
Hs Code.:

Acetic acid, (4-((2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-, (1-((4-(4-chlorophenyl)-1-piperazinyl)methyl)-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide

Synonyms:BRN 4899863;Acetic acid, (4-((2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-, (1-((4-(4-chlorophenyl)-1-piperazinyl)methyl)-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide;136603-18-4;C42H34ClN7O4;C42-H34-Cl-N7-O4

Suppliers and Price of Acetic acid, (4-((2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-, (1-((4-(4-chlorophenyl)-1-piperazinyl)methyl)-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Acetic acid, (4-((2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-, (1-((4-(4-chlorophenyl)-1-piperazinyl)methyl)-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide

Chemical Property:

XLogP3:8.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:10
Exact Mass:735.2360803
Heavy Atom Count:54
Complexity:1260

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1CN2C3=CC=CC=C3C(=C2O)N=NC(=O)COC4=CC=C(C=C4)C(=O)C5=C(N=C6C(=C5)C=CC=N6)C7=CC=CC=C7)C8=CC=C(C=C8)Cl

Technology Process of Acetic acid, (4-((2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-, (1-((4-(4-chlorophenyl)-1-piperazinyl)methyl)-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide

There total 6 articles about Acetic acid, (4-((2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-, (1-((4-(4-chlorophenyl)-1-piperazinyl)methyl)-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7521-41-7
2-Aminonicotinaldehyde

: 136603-18-4
[4-(2-Phenyl-[1,8]naphthyridine-3-carbonyl)-phenoxy]-acetic acid [1-[4-(4-chloro-phenyl)-piperazin-1-ylmethyl]-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide

Guidance literature:: Multi-step reaction with 5 steps

1: conc. H₂SO₄, glac. AcOH

2: 65 percent / K₂CO₃ / acetone / 18 h / Heating

3: 60 percent / hydrazine hydrate / methanol / 8 h / Heating

4: 68 percent / glac. AcOH / methanol / 4 h / Heating

5: dimethylformamide; H₂O / 1) heating, 10 min, 2) r.t., overnight

With sulfuric acid; potassium carbonate; hydrazine hydrate; acetic acid; In methanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 52046-71-6
1-(4-hydroxy-phenyl)-3-phenyl-propane-1,3-dione

: 136603-18-4
[4-(2-Phenyl-[1,8]naphthyridine-3-carbonyl)-phenoxy]-acetic acid [1-[4-(4-chloro-phenyl)-piperazin-1-ylmethyl]-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide

Guidance literature:: Multi-step reaction with 5 steps

1: conc. H₂SO₄, glac. AcOH

2: 65 percent / K₂CO₃ / acetone / 18 h / Heating

3: 60 percent / hydrazine hydrate / methanol / 8 h / Heating

4: 68 percent / glac. AcOH / methanol / 4 h / Heating

5: dimethylformamide; H₂O / 1) heating, 10 min, 2) r.t., overnight

With sulfuric acid; potassium carbonate; hydrazine hydrate; acetic acid; In methanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 116625-85-5
3-p-Hydroxybenzoyl-2-phenyl-1,8-naphthyridine

: 136603-18-4
[4-(2-Phenyl-[1,8]naphthyridine-3-carbonyl)-phenoxy]-acetic acid [1-[4-(4-chloro-phenyl)-piperazin-1-ylmethyl]-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / K₂CO₃ / acetone / 18 h / Heating

2: 60 percent / hydrazine hydrate / methanol / 8 h / Heating

3: 68 percent / glac. AcOH / methanol / 4 h / Heating

4: dimethylformamide; H₂O / 1) heating, 10 min, 2) r.t., overnight

With potassium carbonate; hydrazine hydrate; acetic acid; In methanol; water; N,N-dimethyl-formamide; acetone;