CHEMBRDG-BB 9024416

Base Information

• Chemical Name: CHEMBRDG-BB 9024416
• CAS No.: 890014-20-7
• Molecular Formula: C₉H₈N₂O₂S₂
• Molecular Weight: 240.307
• Mol file: 890014-20-7.mol

Synonyms:

Chemical Property of CHEMBRDG-BB 9024416

Chemical Property:

• Vapor Pressure: 2.42E-09mmHg at 25°C
• Boiling Point: 462.3±45.0 °C(Predicted)
• PKA: 3.04±0.10(Predicted)
• Density: 1.52±0.1 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

[(6-methylthieno[2,3-d]pyrimidin-4-yl)thio]aceticacid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CHEMBRDG-BB 9024416

There total 7 articles about CHEMBRDG-BB 9024416 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-6-methylthieno<2,3-d>pyrimidine (106691-21-8) + mercaptoacetic acid (68-11-1) → [(6-methylthieno[2,3-d]pyrimidin-4-yl)thio]acetic acid (890014-20-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 0.166667h; Heating;

DOI:10.1016/j.ejmech.2010.12.025

Reference yield:

C10H10N2O2S2 → [(6-methylthieno[2,3-d]pyrimidin-4-yl)thio]acetic acid (890014-20-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1016/j.bmcl.2016.02.021

Reference yield:

6-Methylthieno<2,3-d>pyrimid-4-one (108831-66-9) → [(6-methylthieno[2,3-d]pyrimidin-4-yl)thio]acetic acid (890014-20-7)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus pentachloride; trichlorophosphate

2: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / Heating

With phosphorus pentachloride; potassium carbonate; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2010.12.025

upstream raw materials:

ethyl 2-amino-5-methylthiophene-3-carboxylate

4-chloro-6-methylthieno<2,3-d>pyrimidine

mercaptoacetic acid

6-Methylthieno<2,3-d>pyrimid-4-one

Refernces

• 1、 Tarver, James E.,Pabba, Praveen K.,Barbosa, Joseph,Han, Qiang,Gardyan, Michael W.,Brommage, Robert,Thompson, Andrea Y.,Schmidt, James M.,Wilson, Alan G.E.,He, Wei,Lombardo, Victoria K.,Carson, Kenneth G.. "Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase". . p. 1525 - 1528. Retrieved 2016/07/27.
• 2、 Golub, Andriy G.,Bdzhola, Volodymyr G.,Briukhovetska, Nadiia V.,Balanda, Anatoliy O.,Kukharenko, Olexander P.,Kotey, Igor M.,Ostrynska, Olga V.,Yarmoluk, Sergiy M.. "Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin- 4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2". . p. 870 - 876. Retrieved 2011/04/22.