(1R,2R)-2-methoxycyclopentanamine

Base Information

• Chemical Name: (1R,2R)-2-methoxycyclopentanamine
• CAS No.: 1394826-99-3
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.175
• Mol file: 1394826-99-3.mol

Synonyms:

Chemical Property of (1R,2R)-2-methoxycyclopentanamine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-2-methoxycyclopentanamine

There total 2 articles about (1R,2R)-2-methoxycyclopentanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2R)-N,N-dibenzyl-2-methoxycyclopentanamine → (1R,2R)-2-methoxycyclopentanamine (1394826-99-3,1306310-32-6)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/acs.jmedchem.7b01854

Reference yield:

(1R,2R)-2-(dibenzylamino)cyclopentanol → (1R,2R)-2-methoxycyclopentanamine (1394826-99-3,1306310-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 25 °C

1.2: 2 h / 20 °C

2.1: 10 wt% Pd(OH)2 on carbon; hydrogen / tetrahydrofuran / 20 °C

With 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.7b01854

Reference yield:

(1R,2R)-2-methoxycyclopentanamine (1394826-99-3,1306310-32-6) + 6-amino-3-chloro-2-[(1-methylethyl)sulfonyl]phenol + 4-Nitrophenyl chloroformate (7693-46-1) → 1-(4-chloro-2-hydroxy-3-(isopropylsulfonyl)phenyl)-3-((1R,2R)-2-methoxycyclopentyl)urea

Guidance literature:

(1R,2R)-2-methoxycyclopentanamine; 4-Nitrophenyl chloroformate; With pyridine; In dichloromethane; at 20 ℃;

6-amino-3-chloro-2-[(1-methylethyl)sulfonyl]phenol; In N,N-dimethyl-formamide; at 70 ℃; for 72h;

DOI:10.1021/acs.jmedchem.7b01854