4-bromo-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole

Base Information

• Chemical Name: 4-bromo-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole
• CAS No.: 1203556-18-6
• Molecular Formula: C₁₀H₆BrF₃N₂
• Molecular Weight: 291.07
• Mol file: 1203556-18-6.mol

Synonyms:

Chemical Property of 4-bromo-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole

There total 4 articles about 4-bromo-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.5%

4-bromo-1H-pyrazole (2075-45-8) + 4-Iodobenzotrifluoride (455-13-0) → 4-bromo-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole (1203556-18-6)

Guidance literature:

With copper (II) acetate; Cs₂CO₃; In N,N-dimethyl-formamide; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.3389/fonc.2022.835833

Reference yield: 36.5%

1-(4-trifluoromethyl-phenyl)-1H-pyrazole (207797-05-5) → 4-bromo-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole (1203556-18-6)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 48h;

Reference yield:

4-bromo-1H-pyrazole (2075-45-8) + p-trifluoromethylphenyl bromide (402-43-7) → 4-bromo-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole (1203556-18-6)

Guidance literature:

With caesium carbonate; copper(I) oxide; salicylaldehyde-oxime; In acetonitrile; at 110 ℃; for 72h;

upstream raw materials:

4-bromo-1H-pyrazole

p-trifluoromethylphenyl bromide

4-Fluorobenzotrifluoride

1-(4-trifluoromethyl-phenyl)-1H-pyrazole

Downstream raw materials:

1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-amine

Refernces

• 1、 -. "INHIBITOR COMPOUNDS". . . Retrieved 2021/01/29.