684238-37-7

Base Information

• Chemical Name: 684238-37-7
• CAS No.: 684238-37-7
• Molecular Formula: C₃₁H₃₄O₄
• Molecular Weight: 470.609
• Mol file: 684238-37-7.mol

Synonyms:

Chemical Property of 684238-37-7

Chemical Property:

• Boiling Point: 627.0±55.0 °C(Predicted)
• Density: 1.19±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

BMS 986187 ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 684238-37-7

There total 4 articles about 684238-37-7 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-(4-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione (37797-12-9) + 2-methylbenzyl bromide (89-92-9) → 3,3,6,6-tetramethyl-9-(4-((2-methylbenzyl)oxy)phenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione (684238-37-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 15h;

DOI:10.1021/acs.jmedchem.5b00007

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 3,3,6,6-tetramethyl-9-(4-((2-methylbenzyl)oxy)phenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione (684238-37-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / isopropyl alcohol / 85 °C

2: caesium carbonate / N,N-dimethyl-formamide / 15 h / 25 °C

With sulfuric acid; caesium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/acs.jmedchem.5b00007

Reference yield:

dimedone (126-81-8) → 3,3,6,6-tetramethyl-9-(4-((2-methylbenzyl)oxy)phenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione (684238-37-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / isopropyl alcohol / 85 °C

2: caesium carbonate / N,N-dimethyl-formamide / 15 h / 25 °C

With sulfuric acid; caesium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/acs.jmedchem.5b00007

upstream raw materials:

9-(4-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione

2-methylbenzyl bromide

4-hydroxy-benzaldehyde

dimedone