37797-12-9

Basic information

• Product Name: 9-(4-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
• Synonyms: 9-(4-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
• CAS NO: 37797-12-9
• Molecular Formula: C₂₃H₂₆O₄
• Molecular Weight: 366.45014
• Mol File: 37797-12-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9-(4-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 9-(4-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione(37797-12-9)
• EPA Substance Registry System: 9-(4-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione(37797-12-9)

Safety Data

• Hazardous Substances Data: 37797-12-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
9-(4-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione is used as a key intermediate in the synthesis of BMS 986187 (B596400), a selective positive allosteric modulator of the δ-opioid receptor. This application is significant because it targets the development of novel therapeutics for pain management and other conditions that can be alleviated through modulation of the δ-opioid receptor.
9-(4-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione's role in the synthesis of BMS 986187 highlights its importance in the pharmaceutical industry, as it contributes to the development of innovative drugs with potential applications in treating various medical conditions. The selective modulation of the δ-opioid receptor by BMS 986187 could lead to improved treatment options with fewer side effects compared to traditional opioid medications, making 9-(4-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione a valuable asset in the ongoing quest for better pain management solutions.

Upstream product

• 329736-70-1 (4-hydroxybenzylidene)bis(dimedone) 
• 315671-83-1 C₂₃H₂₈O₅ 
• 2878-50-4 α-(4-hydroxyphenyl)-N-phenyl nitrone 
• 126-81-8 dimedone 
• 7560-94-3 2,2'-((4-methoxyphenyl)methylene)bis(3-hydroxy-5,5-dimethylcyclohex-2-enone) 
• 504-02-9 1,3-cylohexanedione 
• 123-08-0 4-hydroxy-benzaldehyde 
• 63-74-1 sulfanilamide 
• 100-46-9 benzylamine 
• 1689-73-2 N-(p-hydroxybenzylidene)aniline 
• 71827-75-3 2,2′‐[(4‐hydroxyphenyl)methylene]bis(3‐hydroxy‐5,5‐dimethylcyclohex‐2‐enone) 

Downstream Products

• 341956-74-9 3,3,6,6-tetramethyl-9-(4-benzyloxyphenyl)-1,8-dioxooctahydroxanthene 
• 684238-37-7 3,3,6,6-tetramethyl-9-(4-((2-methylbenzyl)oxy)phenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione 
• 1352134-61-2 4-[4-(3,3,6,6-tetramethyl-1,8-dioxo-2,3,4,5,6,7,8,9-octahydro-1H-xanthen-9-yl)phenoxy]phthalonitrile 

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