N-(4-methyl-9H-xanthen-9-yl)-2-chloroethanamide

Base Information

• Chemical Name: N-(4-methyl-9H-xanthen-9-yl)-2-chloroethanamide
• CAS No.: 154420-61-8
• Molecular Formula: C₁₆H₁₄ClNO₂
• Molecular Weight: 287.746
• Mol file: 154420-61-8.mol

Synonyms:

Chemical Property of N-(4-methyl-9H-xanthen-9-yl)-2-chloroethanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-methyl-9H-xanthen-9-yl)-2-chloroethanamide

There total 5 articles about N-(4-methyl-9H-xanthen-9-yl)-2-chloroethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-methyl-9-hydroxy-9H-xanthene (107409-98-3) + Chloroacetamide (79-07-2) → N-(4-methyl-9H-xanthen-9-yl)-2-chloroethanamide (154420-61-8)

Guidance literature:

With acetic acid; 1.) 100 deg C, 2.) r.t., overnight;

DOI:10.1002/ardp.19943270202

Reference yield:

4-methylxanthen-9-one (5396-28-1) → N-(4-methyl-9H-xanthen-9-yl)-2-chloroethanamide (154420-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Na/Hg / aq. ethanol

2: 63 percent / glacial CH₃COOH / 1.) 100 deg C, 2.) r.t., overnight

With sodium amalgam; acetic acid; In ethanol;

DOI:10.1002/ardp.19943270202

Reference yield:

2-(2-methylphenoxy)benzoic acid (6325-68-4) → N-(4-methyl-9H-xanthen-9-yl)-2-chloroethanamide (154420-61-8)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. H₂SO₄ / Heating

2: Na/Hg / aq. ethanol

3: 63 percent / glacial CH₃COOH / 1.) 100 deg C, 2.) r.t., overnight

With sodium amalgam; sulfuric acid; acetic acid; In ethanol;

DOI:10.1002/ardp.19943270202

upstream raw materials:

4-methyl-9-hydroxy-9H-xanthene

Chloroacetamide

4-methylxanthen-9-one

2-(2-methylphenoxy)benzoic acid

Refernces