2-BROMO-3-METHOXYANILINE HYDROCHLORIDE

Base Information

• Chemical Name: 2-BROMO-3-METHOXYANILINE HYDROCHLORIDE
• CAS No.: 67853-38-7
• Molecular Formula: C₇H₈BrNO*ClH
• Molecular Weight: 238.512
• Mol file: 67853-38-7.mol

Synonyms:

Chemical Property of 2-BROMO-3-METHOXYANILINE HYDROCHLORIDE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-3-methoxyaniline hydrochloride >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-BROMO-3-METHOXYANILINE HYDROCHLORIDE

There total 2 articles about 2-BROMO-3-METHOXYANILINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N-(2-bromo-3-methoxyphenyl)-2,2-dimethylpropionamide (168335-61-3) → 2-bromo-3-methoxyphenylamine hydrochloride (67853-38-7)

Guidance literature:

With hydrogenchloride; In diethylene glycol dimethyl ether; water; at 100 ℃; for 24h;

Reference yield:

2-Bromo-3-methoxyacetanilide (150637-99-3) → 2-bromo-3-methoxyphenylamine hydrochloride (67853-38-7)

Guidance literature:

With hydrogenchloride; water; In ethanol; for 6 - 8h; Heating / reflux;

Reference yield:

2-bromo-3-methoxyphenylamine hydrochloride (67853-38-7) → 2-methoxy-6-methylthiobenzaldehyde (67853-41-2)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) NaNO₂, aq. HCl, (ii) EtOCS₂K, H₂O, (iii) aq. NaOH, EtOH

2: aq. NaOH

3: (i) Mg, THF, (ii) /BRN= 1867782/

With sodium hydroxide;

DOI:10.1246/bcsj.51.2437

upstream raw materials:

2-Bromo-3-methoxyacetanilide

N-(2-bromo-3-methoxyphenyl)-2,2-dimethylpropionamide

Downstream raw materials:

2-Brom-3-methoxy-thiophenol

2-methoxy-6-methylthiobenzaldehyde

2-Brom-3-methylthio-anisol

Refernces

• 1、 -. "PROCESS FOR PREPARING SUBSTITUTED ANISIDINES". Page/Page column 7-8. . Retrieved 2008/06/13.