C₂₀H₂₅N₂O⁽¹⁺⁾*I^(1-)

Base Information

• Chemical Name: C₂₀H₂₅N₂O⁽¹⁺⁾*I^(1-)
• CAS No.: 107893-05-0
• Molecular Formula: C₂₀H₂₅N₂O*I
• Molecular Weight: 436.336
• Mol file: 107893-05-0.mol

Synonyms:

Chemical Property of C₂₀H₂₅N₂O⁽¹⁺⁾*I^(1-)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₅N₂O⁽¹⁺⁾*I^(1-)

There total 15 articles about C₂₀H₂₅N₂O⁽¹⁺⁾*I^(1-) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,12bS)-3-Eth-(E)-ylidene-4-oxo-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine-2-carbaldehyde (79228-07-2) → C20H25N2O(1+)*I(1-) (7240-76-8,80264-66-0,107893-05-0)

Guidance literature:

Multi-step reaction with 13 steps

1: BF₃*Et₂O / CH₂Cl₂ / 0 °C

2: i-Bu₂AlH / 1,2-dimethoxy-ethane / -55 °C

3: NaBH₃CN / tetrahydrofuran / from -70 up to room temp.

4: CH₃I, CaCO₃ / H₂O; acetone / Ambient temperature

5: H₂O; tetrahydrofuran

6: CH₂Cl₂; pyridine

7: LiCl / dimethylformamide / 110 °C

8: 64 percent / NaH / dimethylsulfoxide / Ambient temperature

9: 54 percent / 1-chlorobenzotriazole, Et₃N / CH₂Cl₂ / Ambient temperature

10: KOH / aq. ethanol

11: BF₃

12: LiAlH₄

13: methanol

With potassium hydroxide; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; boron trifluoride; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; N-chlorobenzotriazole; calcium carbonate; lithium chloride; methyl iodide; In tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

DOI:10.1016/S0040-4039(01)90397-1

Reference yield:

(2R,12bS)-2-[1,3]Dithiolan-2-yl-3-eth-(E)-ylidene-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine (79235-45-3) → C20H25N2O(1+)*I(1-) (7240-76-8,80264-66-0,107893-05-0)

Guidance literature:

Multi-step reaction with 11 steps

1: NaBH₃CN / tetrahydrofuran / from -70 up to room temp.

2: CH₃I, CaCO₃ / H₂O; acetone / Ambient temperature

3: H₂O; tetrahydrofuran

4: CH₂Cl₂; pyridine

5: LiCl / dimethylformamide / 110 °C

6: 64 percent / NaH / dimethylsulfoxide / Ambient temperature

7: 54 percent / 1-chlorobenzotriazole, Et₃N / CH₂Cl₂ / Ambient temperature

8: KOH / aq. ethanol

9: BF₃

10: LiAlH₄

11: methanol

With potassium hydroxide; lithium aluminium tetrahydride; boron trifluoride; sodium hydride; sodium cyanoborohydride; triethylamine; N-chlorobenzotriazole; calcium carbonate; lithium chloride; methyl iodide; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

DOI:10.1016/S0040-4039(01)90397-1

Reference yield:

C19H21N3O (80249-88-3) → C20H25N2O(1+)*I(1-) (7240-76-8,80264-66-0,107893-05-0)

Guidance literature:

Multi-step reaction with 3 steps

1: BF₃

2: LiAlH₄

3: methanol

With lithium aluminium tetrahydride; boron trifluoride; In methanol;

DOI:10.1016/S0040-4039(01)90397-1

upstream raw materials:

(+/-)-normavacurine

methyl iodide

(2R,12bS)-3-Eth-(E)-ylidene-4-oxo-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine-2-carbaldehyde

(2R,12bS)-2-[1,3]Dithiolan-2-yl-3-eth-(E)-ylidene-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine