N-[2-(1,3-benzodioxol-5-yl)ethyl]-2-(4-methoxyphenyl)acetamide

Base Information

• Chemical Name: N-[2-(1,3-benzodioxol-5-yl)ethyl]-2-(4-methoxyphenyl)acetamide
• CAS No.: 20341-14-4
• Molecular Formula: C18H19 N O4
• Molecular Weight: 313.3478
• Mol file: 20341-14-4.mol

Synonyms:Acetamide,2-(p-methoxyphenyl)-N-[3,4-(methylenedioxy)phenethyl]- (7CI,8CI); NSC 149609

Chemical Property of N-[2-(1,3-benzodioxol-5-yl)ethyl]-2-(4-methoxyphenyl)acetamide

Chemical Property:

• Vapor Pressure: 4.38E-12mmHg at 25°C
• Boiling Point: 548.6°C at 760 mmHg
• Flash Point: 285.6°C
• Density: 1.218g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[2-(1,3-benzodioxol-5-yl)ethyl]-2-(4-methoxyphenyl)acetamide

There total 5 articles about N-[2-(1,3-benzodioxol-5-yl)ethyl]-2-(4-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-Methoxyphenylacetic acid (104-01-8) + 3,4-methylenedioxyphenylethylamine (1484-85-1) → N-[2-(1,3-benzodioxol-5-yl)ethyl]-2-(4-methoxyphenyl)acetamide (20341-14-4)

Guidance literature:

4-Methoxyphenylacetic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.333333h; Inert atmosphere;

3,4-methylenedioxyphenylethylamine; In dichloromethane; at 25 ℃; for 4h; Inert atmosphere;

DOI:10.1055/s-2008-1067162

Reference yield: 57.0%

3,4-methylenedioxyphenylethylamine (1484-85-1) + 4-methoxyphenyl-acetic chloride (4693-91-8) → N-[2-(1,3-benzodioxol-5-yl)ethyl]-2-(4-methoxyphenyl)acetamide (20341-14-4)

Guidance literature:

With sodium hydroxide; In chloroform; water;

DOI:10.1002/anie.201507970

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) → N-[2-(1,3-benzodioxol-5-yl)ethyl]-2-(4-methoxyphenyl)acetamide (20341-14-4)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 21 °C / Inert atmosphere

2: sodium hydroxide / water; chloroform

With oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In chloroform; water; toluene;

DOI:10.1002/anie.201507970

upstream raw materials:

2-diazo-1-(4-methoxyphenyl)ethanone

3,4-methylenedioxyphenylethylamine

4-methoxyphenyl-acetic chloride

4-Methoxyphenylacetic acid

Downstream raw materials:

(7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)(4-methoxyphenyl)methanone

5-(4-methoxybenzyl)-7,8-dihydro[1,3]dioxolo[4,5-g]isoquinoline

(6,7-methylenedioxyisoquinolinyl)-(4'-methoxyphenyl)-methanone