2-(3-Benzyltriazolo[4,5-d]pyrimidin-7-yl)sulfanyl-1,3-benzoxazole

Base Information

Chemical Name:2-(3-Benzyltriazolo[4,5-d]pyrimidin-7-yl)sulfanyl-1,3-benzoxazole
CAS No.:722456-31-7
Molecular Formula:C₁₈H₁₂N₆OS
Molecular Weight:360.399
Hs Code.:
European Community (EC) Number:804-251-4
UNII:BN6QHA4JW4
Nikkaji Number:J2.989.174E
ChEMBL ID:CHEMBL4210329
Mol file:722456-31-7.mol

Synonyms:3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine;VAS 2870;VAS-2870;VAS2870

Suppliers and Price of 2-(3-Benzyltriazolo[4,5-d]pyrimidin-7-yl)sulfanyl-1,3-benzoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
VAS2870
1mg
$ 55.00

Tocris
VAS2870 ≥98%(HPLC)
25
$ 261.00

Tocris
VAS2870 ≥98%(HPLC)
5
$ 67.00

Sigma-Aldrich
VAS2870 ≥97% (HPLC)
5mg
$ 78.20

Sigma-Aldrich
NOX Inhibitor III, VAS2870 - CAS 722456-31-7 - Calbiochem The NOX Inhibitor III, VAS2870, also referenced under CAS 722456-31-7, controls the biological activity of NOX.
10 mg
$ 135.00

Sigma-Aldrich
NOX Inhibitor III, VAS2870
10mg-m
$ 135.00

Sigma-Aldrich
VAS2870 ≥97% (HPLC)
25mg
$ 318.00

DC Chemicals
VAS2870 >98%
100 mg
$ 500.00

DC Chemicals
VAS2870 >98%
1 g
$ 1700.00

DC Chemicals
VAS2870 >98%
250 mg
$ 900.00

Total 16 raw suppliers

Chemical Property of 2-(3-Benzyltriazolo[4,5-d]pyrimidin-7-yl)sulfanyl-1,3-benzoxazole

Chemical Property:

Boiling Point:627.0±65.0 °C(Predicted)
PKA:0.85±0.30(Predicted)
Density:1.53±0.1 g/cm3(Predicted)
Storage Temp.:room temp
Solubility.:DMSO: ≥5mg/mL
XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:360.07933020
Heavy Atom Count:26
Complexity:479

Purity/Quality:

98%,99%, ^*data from raw suppliers

VAS2870 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CN2C3=C(C(=NC=N3)SC4=NC5=CC=CC=C5O4)N=N2
Description VAS-2870 (722456-31-7) is a NAD(P)H oxidase (Nox) inhibitor. Abolishes PDGF-mediated Nox activation and ROS production (100% at 10 μM). Inhibits PMA-induced oxidative burst in HL-60 cells (IC50=2 μM). VAS-2870 enhances TGF-β-induced apoptosis in liver tumor cells.
Uses VAS 2870, is a NADPH oxidase (NOX) inhibitor. VAS2870 has been used as a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) inhibitor: to study the importance of NOX-derived reactive oxygen species in cytoskeletal organization, proper localization of E-cadherin and cell motility during zebrafish epiboly to study the function of Nox2 and Nox4 in lipopolysaccharide (LPS)-induced intestinal injury in high-fat diet (HFD) fed miceto reduce the reactive oxygen species level and study its influence on inhibiting the induction of trained innate immunity in monocytes

Technology Process of 2-(3-Benzyltriazolo[4,5-d]pyrimidin-7-yl)sulfanyl-1,3-benzoxazole

There total 1 articles about 2-(3-Benzyltriazolo[4,5-d]pyrimidin-7-yl)sulfanyl-1,3-benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%