1-hydroxy-isoquinolin-3-orthocarboxylic acid trimethyl ester

Base Information

• Chemical Name: 1-hydroxy-isoquinolin-3-orthocarboxylic acid trimethyl ester
• CAS No.: 847783-41-9
• Molecular Formula: C₁₃H₁₅NO₄
• Molecular Weight: 249.266
• Mol file: 847783-41-9.mol

Synonyms:

Chemical Property of 1-hydroxy-isoquinolin-3-orthocarboxylic acid trimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-hydroxy-isoquinolin-3-orthocarboxylic acid trimethyl ester

There total 1 articles about 1-hydroxy-isoquinolin-3-orthocarboxylic acid trimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-methyl 2-[(5-oxo-2-phenyloxazol-4(5H)-ylidene)-methyl]-benzoate (88590-43-6) → 1-hydroxy-isoquinoline-3-carboxylic acid (7509-13-9) + 1-hydroxy-isoquinolin-3-orthocarboxylic acid trimethyl ester (847783-41-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium acetate; acetic acid

2: aq. NaOH solution / anschliessend Ansaeuern mit wss. Salzsaeure

3: ethanolic NH₃ / 130 °C

With sodium hydroxide; ammonia; sodium acetate; acetic acid;

DOI:10.1039/jr9510001213

Reference yield:

1-hydroxy-isoquinolin-3-orthocarboxylic acid trimethyl ester (847783-41-9) → 1-hydroxy-isoquinoline-3-carboxylic acid (7509-13-9)

Guidance literature:

With potassium hydroxide;

DOI:10.1039/jr9370000473

Reference yield:

1-hydroxy-isoquinolin-3-orthocarboxylic acid trimethyl ester (847783-41-9) → ethyl 1-hydroxyisoquinoline-3-carboxylate (94726-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous KOH

2: ethanol; H₂SO₄

With potassium hydroxide; ethanol; sulfuric acid;

DOI:10.1039/jr9370000473

upstream raw materials:

(Z)-methyl 2-[(5-oxo-2-phenyloxazol-4(5H)-ylidene)-methyl]-benzoate

Downstream raw materials:

1-hydroxy-isoquinoline-3-carboxylic acid

ethyl 1-hydroxyisoquinoline-3-carboxylate