7509-13-9

Usage

Uses

Used in Pharmaceutical Industry:
1-OXO-1,2-DIHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID is used as a building block for the synthesis of various pharmaceuticals and biologically active compounds. Its unique structure and functional groups make it a valuable component in the development of new drugs and therapies.
Used in Organic Synthesis:
1-OXO-1,2-DIHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID is used as a key intermediate in organic synthesis, allowing for the creation of a wide range of chemical compounds. Its versatility and reactivity make it a valuable asset in the synthesis of various organic molecules.
Used in Research and Development:
1-OXO-1,2-DIHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID is used as a research tool in the development of new drugs and therapies. Its potential pharmacological properties make it a promising candidate for further investigation and application in the medical field.

InChI:InChI=1/C10H7NO3/c12-9-7-4-2-1-3-6(7)5-8(11-9)10(13)14/h1-5H,(H,11,12)(H,13,14)

Upstream product

• 847783-41-9 1-hydroxy-isoquinolin-3-orthocarboxylic acid trimethyl ester 
• 100727-89-7 1-hydroxy-isoquinoline-3,4-dicarboxylic acid-4-ethyl ester 
• 69454-42-8 methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate 
• 2289-03-4 1-oxo-1H-isochromene-3-carboxylic acid 
• 88590-43-6 (Z)-methyl 2-[(5-oxo-2-phenyloxazol-4(5H)-ylidene)-methyl]-benzoate 
• 4361-85-7 1-oxo-1H-isothiochromene-3-carboxylic acid 
• 101094-24-0 3,4-Diethoxycarbonyl-isocumarin 
• 41234-80-4 1-oxo-1H-isochromene-3,4-dicarboxylic acid 4-ethyl ester 
• 56661-83-7 2-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-benzoic acid 
• 14961-34-3 diethyl homophthalate 

Downstream Products

• 119-65-3 isoquinoline 
• 94726-24-6 ethyl 1-hydroxyisoquinoline-3-carboxylate 
• 491-30-5 1-hydroxyisoquinoline 
• 1090010-40-4 N-benzyl-1-oxo-1,2-dihydroisoquinoline-3-carboxamide 

Relevant academic research and scientific papers

SUBSTITUTED 2- AMIDOQUINAZOL-4-ONES AS MATRIX METALLOPROTEINASE-13 INHIBITORS

The present invention provides a novel amide derivative having a matrix metalloproteinase inhibitory activity, and useful as a pharmaceutical agent, which is a compound represented by the formula (I) wherein ring A is an optionally substituted, nitrogen containing heterocycle, ring B is an optionally substituted monocyclic homocycle or an optionally substituted monocyclic heterocycle, Z is N or NR1 (R1 is a hydrogen atom or an optionally substituted hydrocarbon group), is a single bond or a double bond, R2 is a hydrogen atom or an optionally substituted hydrocarbon group, X is an optionally substituted spacer having 1 to 6 atoms, ring C is (1) an optionally substituted homocycle or (2) an optionally substituted heterocycle other than a ring represented by (II) (X′ is S, O, SO, or CH2), and at least one of ring B and ring C has substituent(s), provided that N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]2 hydroxypropyl}5,6 dimethyl 4 oxo 1,4 dihydrothieno[2,3-d]pyrimidine-2-carboxamide is excluded, or a salt thereof.

Design, synthesis, and in vitro evaluation of potential west nile virus protease inhibitors based on the 1-oxo-1,2,3,4-tetrahydroisoquinoline and 1-oxo-1,2-dihydroisoquinoline scaffolds

The 1-oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline scaffolds were utilized in the design and solution phase synthesis of focused libraries of compounds for screening against West Nile Virus (WNV) protease. Exploratory studies have led to the identification of a WNV protease inhibitor (a 1-oxo-1, 2-dihydroisoquinoline-based derivative, 12j) which could potentially serve as a launching pad for a hit-to-lead optimization campaign. The identified hit was devoid of any inhibitory activity toward a panel of mammalian serine proteases.

VIRAL AND FUNGAL INHIBITORS

Novel classes of viral and fungal inhibitors are disclosed. These compounds are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus, and fungal infections such as, for example, candidiasis.

TRISUBSTITUTED AMINE COMPOUND

The present invention relates to a compound of the general formula (1): wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted heterocyclic group, and the like; R1 is an optionally substituted alkyl group, wherein the alkyl group further may optionally be substituted by an optionally substituted homocyclic group, and the like; and R2 is an optionally substituted amino group, and the like; or a pharmaceutically acceptable derivative thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP), thereby being useful for prophylaxis and/or treatment of arteriosclerotic diseases, hyperlipemia or dyslipidemia, and the like.

The practical use of a glycine anion equivalent for the preparation of 3-carboxy-1,2-dihydro-1-oxoisoquinoline

Reaction of the dianion derived from N-Cbz-glycine ethyl ester with 2- carboxybenzaldehyde gave the 2-(phthalidyl)glycinate derivative 8 as the major product. Successive treatment of the latter with LiOH and CF3CO2H/CF3SO

Anti-allergic-3-carboxy-isocoumarin compositions and methods of use

3-Carboxyisocoumarins, 2-thiaisocoumarins and related isocarbostyrils are useful anti-allergic agents. Several of these compounds are novel, and a process for their preparation is provided.