N-[2-(Diethoxyphosphinyl)phenyl]glycine ethyl ester

Base Information

Chemical Name:N-[2-(Diethoxyphosphinyl)phenyl]glycine ethyl ester
CAS No.:140150-92-1
Molecular Formula:C14H22NO5P
Molecular Weight:315.306
Hs Code.:
DSSTox Substance ID:DTXSID601224788
Mol file:140150-92-1.mol

Synonyms:N-[2-(Diethoxyphosphinyl)phenyl]glycine ethyl ester;SCHEMBL9445931;DTXSID601224788;140150-92-1

Suppliers and Price of N-[2-(Diethoxyphosphinyl)phenyl]glycine ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(Diethoxyphosphinyl)phenyl]glycine ethyl ester

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:315.12355980
Heavy Atom Count:21
Complexity:353

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)CNC1=CC=CC=C1P(=O)(OCC)OCC

Technology Process of N-[2-(Diethoxyphosphinyl)phenyl]glycine ethyl ester

There total 3 articles about N-[2-(Diethoxyphosphinyl)phenyl]glycine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.0%

: 2521-90-6
ethyl 2-((2-bromophenyl)amino)acetate

: 762-04-9
phosphonic acid diethyl ester

: 140150-92-1
ethyl N-<2-(diethoxyphosphinyl)phenyl>glycinate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In toluene; at 115 - 120 ℃; for 16h;
DOI:10.1021/jm00086a005

Reference yield:

: 615-36-1
2-bromoaniline

: 140150-92-1
ethyl N-<2-(diethoxyphosphinyl)phenyl>glycinate

Guidance literature:: Multi-step reaction with 2 steps

1: 22 percent / triethylamine, (dimethylamino)pyridine (DMAP) / ethanol / Heating

2: 1 percent / triethylamine, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene / 16 h / 115 - 120 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In ethanol; toluene;
DOI:10.1021/jm00086a005