3-methoxy-5,6,7,8-tetrahydro-naphthalene-2-sulfonic acid diethyl amide

Base Information

• Chemical Name: 3-methoxy-5,6,7,8-tetrahydro-naphthalene-2-sulfonic acid diethyl amide
• CAS No.: 574001-91-5
• Molecular Formula: C₁₅H₂₃NO₃S
• Molecular Weight: 297.419
• Mol file: 574001-91-5.mol

Synonyms:

Chemical Property of 3-methoxy-5,6,7,8-tetrahydro-naphthalene-2-sulfonic acid diethyl amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methoxy-5,6,7,8-tetrahydro-naphthalene-2-sulfonic acid diethyl amide

There total 2 articles about 3-methoxy-5,6,7,8-tetrahydro-naphthalene-2-sulfonic acid diethyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

diethylamine (109-89-7) + 3-methoxy-5,6,7,8-tetrahydro-naphthalene-2-sulfonyl chloride (88040-90-8) → 3-methoxy-5,6,7,8-tetrahydro-naphthalene-2-sulfonic acid diethyl amide (574001-91-5)

Guidance literature:

In dichloromethane; for 0.5h;

DOI:10.1021/jo0340206

Reference yield:

6-methoxy-1,2,3,4-tetrahydronaphthalene (1730-48-9) → 3-methoxy-5,6,7,8-tetrahydro-naphthalene-2-sulfonic acid diethyl amide (574001-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / chlorosulfonic acid / CH₂Cl₂ / 0.17 h / cooling

2: 87 percent / CH₂Cl₂ / 0.5 h

With chlorosulfonic acid; In dichloromethane;

DOI:10.1021/jo0340206

Reference yield: 34.0%

3-methoxy-5,6,7,8-tetrahydro-naphthalene-2-sulfonic acid diethyl amide (574001-91-5) → 3-methoxynaphthalene-2-sulfonic acid diethyl amide

Guidance literature:

3-methoxy-5,6,7,8-tetrahydro-naphthalene-2-sulfonic acid diethyl amide; With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 2h; Heating;

With potassium acetate; In methanol; for 1h; Heating;

With hydrogenchloride; In ethanol; for 1h; Heating;

DOI:10.1021/jo0340206

upstream raw materials:

diethylamine

3-methoxy-5,6,7,8-tetrahydro-naphthalene-2-sulfonyl chloride

6-methoxy-1,2,3,4-tetrahydronaphthalene