Technology Process of 1-(5-(4-fluorophenyl)furan-2-yl)-N-(piperidin-4-ylmethyl)methanamine
There total 12 articles about 1-(5-(4-fluorophenyl)furan-2-yl)-N-(piperidin-4-ylmethyl)methanamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C
1.2: 12 h / 0 - 25 °C
2.1: cerium(III) chloride; sodium iodide / acetonitrile / 12 h / Reflux
3.1: sodium tetrahydroborate; methanol / 1 h / 0 - 25 °C
4.1: triethylamine / dichloromethane / 12 h / 0 - 25 °C
5.1: sodium azide / N,N-dimethyl-formamide / 12 h / 0 - 90 °C
6.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 25 °C / 760.05 Torr
7.1: methanol / 12 h / Reflux
8.1: sodium tetrahydroborate; methanol / 1 h / 0 °C
9.1: acetyl chloride / methanol / 4 h / 0 - 25 °C
With
methanol; sodium tetrahydroborate; sodium azide; cerium(III) chloride; palladium 10% on activated carbon; hydrogen; sodium hexamethyldisilazane; triethylamine; acetyl chloride; sodium iodide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
1.1: |Wittig Olefination / 1.2: |Wittig Olefination;
DOI:10.1016/j.ejmech.2018.03.024
- Guidance literature:
-
Multi-step reaction with 3 steps
1: methanol / 12 h / Reflux
2: sodium tetrahydroborate; methanol / 1 h / 0 °C
3: acetyl chloride / methanol / 4 h / 0 - 25 °C
With
methanol; sodium tetrahydroborate; acetyl chloride;
In
methanol;
DOI:10.1016/j.ejmech.2018.03.024
