tert-butyl 4-(azidomethyl)piperidine-1-carboxylate(SALTDATA: FREE)

Base Information

• Chemical Name: tert-butyl 4-(azidomethyl)piperidine-1-carboxylate(SALTDATA: FREE)
• CAS No.: 325290-50-4
• Molecular Formula: C₁₁H₂₀N₄O₂
• Molecular Weight: 240.305
• Hs Code.: 2933399090
• Mol file: 325290-50-4.mol

Synonyms:tert-butyl 4-(azidomethyl)piperidine-1-carboxylate(SALTDATA: FREE);tert-Butyl 4-(azidomethyl)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-(azidomethyl)piperidine-1-carboxylate(SALTDATA: FREE)

Chemical Property:

• PSA: 79.29000
• LogP: 2.33446

Purity/Quality:

99.3% ^*data from raw suppliers

tert-Butyl 4-(azidomethyl)piperidine-1-carboxylate Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(azidomethyl)piperidine-1-carboxylate(SALTDATA: FREE)

There total 10 articles about tert-butyl 4-(azidomethyl)piperidine-1-carboxylate(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate (161975-39-9) → tert-butyl 4-(azidomethyl)piperidine-1-carboxylate (325290-50-4)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 5h;

DOI:10.1039/b809006h

Reference yield:

tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate (123855-51-6) → tert-butyl 4-(azidomethyl)piperidine-1-carboxylate (325290-50-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0 °C

2: NaN₃ / dimethylformamide / Heating

With sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00661-8

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-(azidomethyl)piperidine-1-carboxylate (325290-50-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / CH₂Cl₂

2: 100 percent / BH₃*THF / tetrahydrofuran

3: Et₃N / CH₂Cl₂ / 0 °C

4: NaN₃ / dimethylformamide / Heating

With sodium azide; borane-THF; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00661-8

upstream raw materials:

tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate

isonipecotic acid

di-tert-butyl dicarbonate

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

Downstream raw materials:

N-tert-butyloxycarbonyl-4-(4-amino-5-chloro-2-methoxyphenylcarbonylaminomethyl)piperidine

N-((1-(3-(1,2,4-triazol-1-yl)propyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide

N-[[1-{3-(1,2,3-triazol-1-yl)propyl}piperidin-4-yl]methyl]-4-amino-5-chloro-2-methoxybenzamide

N-((1-(pyridin-3-ylmethyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide