2-CHLORO-N-ETHYL-N-M-TOLYL-ACETAMIDE

Base Information

• Chemical Name: 2-CHLORO-N-ETHYL-N-M-TOLYL-ACETAMIDE
• CAS No.: 86491-92-1
• Molecular Formula: C₁₁H₁₄ClNO
• Molecular Weight: 211.691
• Mol file: 86491-92-1.mol

Synonyms:

Chemical Property of 2-CHLORO-N-ETHYL-N-M-TOLYL-ACETAMIDE

Chemical Property:

• Melting Point: 109-111 °C
• Boiling Point: 315.8±35.0 °C(Predicted)
• PKA: 0.51±0.50(Predicted)
• Density: 1.142±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-N-ethyl-N-m-tolyl-acetamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

Useful:

Technology Process of 2-CHLORO-N-ETHYL-N-M-TOLYL-ACETAMIDE

There total 1 articles about 2-CHLORO-N-ETHYL-N-M-TOLYL-ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloroacetyl chloride (79-04-9) + N-ethyl-m-toulidine (102-27-2) → 2-chloro-N-ethyl-N-(m-tolyl)acetamide (86491-92-1)

Guidance literature:

With potassium hydroxide; In water; ethyl acetate; at 0 ℃; for 1.16667h;

Reference yield:

2-chloro-N-ethyl-N-(m-tolyl)acetamide (86491-92-1) → ethyl 2-(4-(4-(2-(ethyl(m-tolyl)amino)-2-oxoethyl)-4H-thieno[3,2-b]pyrrole-5-carboxamido)phenyl)acetate

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; 18-crown-6 ether / acetonitrile / 5 h / Reflux

2: lithium hydroxide; water / 1,4-dioxane / 60 °C

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 60 °C

With 18-crown-6 ether; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

2-chloro-N-ethyl-N-(m-tolyl)acetamide (86491-92-1) → methyl 3-(4-(2-(ethyl(m-tolyl)amino)-2-oxoethyl)-4H-thieno[3,2-b]pyrrole-5-carboxamido)benzoate

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; 18-crown-6 ether / acetonitrile / 5 h / Reflux

2: lithium hydroxide; water / 1,4-dioxane / 60 °C

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 60 °C

With 18-crown-6 ether; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

chloroacetyl chloride

N-ethyl-m-toulidine

Refernces