Propanoic acid, 2,2-dimethyl-, 3-[(2S,5S)-tetrahydro-4-methylene-5-[(3R,5R)-5-methyl-3-[(methylsulfonyl)oxy]-6-[[(trifluoromethyl)sulfonyl]oxy]-6-hepten-1-yl]-2-furanyl]propyl ester

Base Information

Chemical Name:Propanoic acid, 2,2-dimethyl-, 3-[(2S,5S)-tetrahydro-4-methylene-5-[(3R,5R)-5-methyl-3-[(methylsulfonyl)oxy]-6-[[(trifluoromethyl)sulfonyl]oxy]-6-hepten-1-yl]-2-furanyl]propyl ester
CAS No.:871357-66-3
Molecular Formula:C₂₃H₃₇F₃O₉S₂
Molecular Weight:578.669
Hs Code.:
Mol file:871357-66-3.mol

Propanoic acid, 2,2-dimethyl-, 3-[(2S,5S)-tetrahydro-4-methylene-5-[(3R,5R)-5-methyl-3-[(methylsulfonyl)oxy]-6-[[(trifluoromethyl)sulfonyl]oxy]-6-hepten-1-yl]-2-furanyl]propyl ester

Synonyms:

Suppliers and Price of Propanoic acid, 2,2-dimethyl-, 3-[(2S,5S)-tetrahydro-4-methylene-5-[(3R,5R)-5-methyl-3-[(methylsulfonyl)oxy]-6-[[(trifluoromethyl)sulfonyl]oxy]-6-hepten-1-yl]-2-furanyl]propyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of Propanoic acid, 2,2-dimethyl-, 3-[(2S,5S)-tetrahydro-4-methylene-5-[(3R,5R)-5-methyl-3-[(methylsulfonyl)oxy]-6-[[(trifluoromethyl)sulfonyl]oxy]-6-hepten-1-yl]-2-furanyl]propyl ester

Chemical Property:

Boiling Point:616.7±55.0 °C(Predicted)
Density:1.27±0.1 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Propanoic acid, 2,2-dimethyl-, 3-[(2S,5S)-tetrahydro-4-methylene-5-[(3R,5R)-5-methyl-3-[(methylsulfonyl)oxy]-6-[[(trifluoromethyl)sulfonyl]oxy]-6-hepten-1-yl]-2-furanyl]propyl ester

There total 13 articles about Propanoic acid, 2,2-dimethyl-, 3-[(2S,5S)-tetrahydro-4-methylene-5-[(3R,5R)-5-methyl-3-[(methylsulfonyl)oxy]-6-[[(trifluoromethyl)sulfonyl]oxy]-6-hepten-1-yl]-2-furanyl]propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 3-((2S,5S)-5-((3R,5R)-3-hydroxy-5-methyl-6-(((trifluoromethyl)sulfonyl)oxy)hept-6-en-1-yl)-4-methylenetetrahydrofuran-2-yl)propyl pivalate

: 124-63-0
methanesulfonyl chloride

: 871357-66-3
C₂₃H₃₇F₃O₉S₂

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃;
DOI:10.1055/s-0032-1317920

Reference yield:

: 871348-26-4
C₇H₁₃BrO₂

: 871357-66-3
C₂₃H₃₇F₃O₉S₂

Guidance literature:: Multi-step reaction with 10 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 15 °C

2: Chiralpak-OD / Resolution of racemate

3: triethylamine; dmap / dichloromethane / 20 °C

4: (R)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide; nickel dichloride; chromium dichloride / tetrahydrofuran / 25 °C

5: silica gel / isopropyl alcohol / 25 °C

6: tetrahydrofuran / 0 °C

7: potassium hexamethylsilazane / toluene; tetrahydrofuran / -70 °C

8: hydrogenchloride / water; isopropyl alcohol / 15 °C

9: dmap; 2,4,6-trimethyl-pyridine / dichloromethane / 0 °C

10: triethylamine / tetrahydrofuran / 0 °C

With 1H-imidazole; 2,4,6-trimethyl-pyridine; chromium dichloride; hydrogenchloride; dmap; (R)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide; silica gel; potassium hexamethylsilazane; triethylamine; nickel dichloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 4: |Nozaki-Hiyama-Kishi Reaction;
DOI:10.1055/s-0032-1317920

Reference yield:

: 871355-14-5
C₂₃H₃₁BrO₂Si

: 871357-66-3
C₂₃H₃₇F₃O₉S₂

Guidance literature:: Multi-step reaction with 11 steps

1: Chiralpak-OD / Resolution of racemate

2: diethylazodicarboxylate; triphenylphosphine / toluene / 0 °C

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

4: triethylamine; dmap / dichloromethane / 20 °C

5: (R)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide; nickel dichloride; chromium dichloride / tetrahydrofuran / 25 °C

6: silica gel / isopropyl alcohol / 25 °C

7: tetrahydrofuran / 0 °C

8: potassium hexamethylsilazane / toluene; tetrahydrofuran / -70 °C

9: hydrogenchloride / water; isopropyl alcohol / 15 °C

10: dmap; 2,4,6-trimethyl-pyridine / dichloromethane / 0 °C

11: triethylamine / tetrahydrofuran / 0 °C

With 2,4,6-trimethyl-pyridine; chromium dichloride; hydrogenchloride; dmap; (R)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide; water; silica gel; potassium hexamethylsilazane; triethylamine; triphenylphosphine; nickel dichloride; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; toluene; 2: |Mitsunobu Displacement / 5: |Nozaki-Hiyama-Kishi Reaction;
DOI:10.1055/s-0032-1317920