(1R,2R,4R)-2-AZIDO-1-ISOPROPYL-4-METHYLCYCLOHEXANE

Base Information

• Chemical Name: (1R,2R,4R)-2-AZIDO-1-ISOPROPYL-4-METHYLCYCLOHEXANE
• CAS No.: 898543-45-8
• Molecular Formula: C₁₀H₁₉N₃
• Molecular Weight: 181.281
• Mol file: 898543-45-8.mol

Synonyms:

Chemical Property of (1R,2R,4R)-2-AZIDO-1-ISOPROPYL-4-METHYLCYCLOHEXANE

Chemical Property:

Purity/Quality:

(1R,2R,4R)-2-AZIDO-1-ISOPROPYL-4-METHYLCYCLOHEXANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R,4R)-2-AZIDO-1-ISOPROPYL-4-METHYLCYCLOHEXANE

There total 23 articles about (1R,2R,4R)-2-AZIDO-1-ISOPROPYL-4-METHYLCYCLOHEXANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

l-menthyl 8-quinolinesulfonate (117800-93-8) → (1S,2R,4R)-2-azido-1-isopropyl-4-methylcyclohexane (898543-45-8,898543-46-9)

Guidance literature:

With trimethylsilylazide; titanium(IV) fluoride; In 1,2-dichloro-ethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.200802472

Reference yield: 95.0%

menthyl tosylate (2230-82-2) → (1S,2S,4R)-2-azido-1-isopropyl-4-methylcyclohexane (107535-12-6,898543-45-8,898543-46-9)

Guidance literature:

With sodium azide; In dimethyl sulfoxide; at 20 ℃; for 36h;

DOI:10.1002/anie.201806059

Reference yield: 94.0%

menthol (89-78-1) → 2-azido-1-isopropyl-4-methylcyclohexane (898543-45-8,898543-46-9)

Guidance literature:

With sodium azide; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; at 90 ℃; for 2h;

DOI:10.1080/00397910008087402

upstream raw materials:

menthyl tosylate

(-)-menthol

(1S,2R,5S)-2-i-propyl-5-methylcyclohexyl 4-methylbenzenesulfonate

(1S,2R,5S)-(+)-menthol

Downstream raw materials:

N-((1S)-neomenthyl)-formamide