N-[[1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl]carbonyl]glycine

Base Information

Chemical Name:N-[[1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl]carbonyl]glycine
CAS No.:931399-19-8
Molecular Formula:C₁₇H₁₇FN₂O₅
Molecular Weight:348.331
Hs Code.:
Mol file:931399-19-8.mol

Synonyms:

Suppliers and Price of N-[[1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl]carbonyl]glycine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
GSK360A
5mg
$ 460.00

TRC
GSK360A
10mg
$ 350.00

Sigma-Aldrich
GSK360A ≥98% (HPLC)
25mg
$ 388.00

Sigma-Aldrich
GSK360A ≥98% (HPLC)
5mg
$ 98.60

Medical Isotopes, Inc.
GSK360A
5 mg
$ 650.00

Total 1 raw suppliers

Chemical Property of N-[[1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl]carbonyl]glycine

Chemical Property:

Melting Point:194-198°C (dec.)
Storage Temp.:2-8°C
Solubility.:Acetone (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:: GSK360A ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses GSK360A orally active HIF-PHD inhibitor. GSK360A exerts systemic and local effects by stabilizing HIF-1α signaling and improves long-term ventricular function, remodeling, and vascularity in a model of established ventricular dysfunction. These findings suggest that GSK360A may be suitable for the treatment of post-MI remodeling and heart failure.

Technology Process of N-[[1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl]carbonyl]glycine

There total 2 articles about N-[[1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl]carbonyl]glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 931399-20-1
ethyl 1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate

: 6000-44-8
sodium glycinate

: 931399-19-8
N-{[1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl]carbonyl}glycine

Guidance literature:: ethyl 1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate; sodium glycinate; In 2-methoxy-ethanol; for 3h; Heating / reflux;

With hydrogenchloride; In 2-methoxy-ethanol; water; Product distribution / selectivity;