Ethyl 1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate

Base Information

Chemical Name:Ethyl 1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate
CAS No.:931399-20-1
Molecular Formula:C₁₇H₁₈FNO₄
Molecular Weight:319.333
Hs Code.:
Mol file:931399-20-1.mol

Synonyms:1-(2-Cyclopropylethyl)-6-fluoro-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxylic Acid Ethyl Ester;Ethyl 1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate

Suppliers and Price of Ethyl 1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(2-Cyclopropylethyl)-6-fluoro-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxylicAcidEthylEster
10mg
$ 150.00

Medical Isotopes, Inc.
1-(2-Cyclopropylethyl)-6-fluoro-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxylicAcidEthylEster
100 mg
$ 2200.00

American Custom Chemicals Corporation
1-(2-CYCLOPROPYLETHYL)-6-FLUORO-1,2-DIHYDRO-4-HYDROXY-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER 95.00%
5MG
$ 497.77

Total 1 raw suppliers

Chemical Property of Ethyl 1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate

Chemical Property:

PSA：68.53000
LogP:2.82300
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:: 1-(2-Cyclopropylethyl)-6-fluoro-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Intermediate in the synthesis of prolyl hydroxylase inhibitors.

Technology Process of Ethyl 1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate

There total 1 articles about Ethyl 1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 477933-12-3
1-(2-cyclopropylethyl)-6-fluoro-1H-benzo[d][1,3]oxazine-2,4-dione

: 105-53-3
diethyl malonate

: 931399-20-1
ethyl 1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate

Guidance literature:: diethyl malonate; With sodium hydride; In N,N-dimethyl acetamide; at 10 - 20 ℃; for 0.5h;

1-(2-cyclopropylethyl)-6-fluoro-1H-benzo[d][1,3]oxazine-2,4-dione; In N,N-dimethyl acetamide; at 120 ℃; for 20h;

Reference yield: 78.0%

: 931399-20-1
ethyl 1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate

: 6000-44-8
sodium glycinate

: 931399-19-8
N-{[1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl]carbonyl}glycine

Guidance literature:: ethyl 1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate; sodium glycinate; In 2-methoxy-ethanol; for 3h; Heating / reflux;

With hydrogenchloride; In 2-methoxy-ethanol; water; Product distribution / selectivity;