Terfenadine Related Compound A (100 mg) (1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-butanone)

Base Information

• Chemical Name: Terfenadine Related Compound A (100 mg) (1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-butanone)
• CAS No.: 76815-60-6
• Molecular Formula: C₃₂H₃₉NO₂
• Molecular Weight: 469.667
• Mol file: 76815-60-6.mol

Synonyms:

Chemical Property of Terfenadine Related Compound A (100 mg) (1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-butanone)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s): 6352257
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

Useful:

Technology Process of Terfenadine Related Compound A (100 mg) (1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-butanone)

There total 6 articles about Terfenadine Related Compound A (100 mg) (1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-butanone) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

terfenadine (50679-08-8) → 4'-tert-butyl-4-[4-(α-hydroxy-α-phenylbenzyl)piperidino]butyrophenone (43076-30-8,76815-60-6)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; triethylamine; In acetone; at 150 ℃; Flow reactor;

DOI:10.1021/acs.oprd.7b00190

Reference yield: 75.0%

C18H21NO (115-46-8) + 1-(4-tert-Butyl-phenyl)-4-iodo-butan-1-one → 4'-tert-butyl-4-[4-(α-hydroxy-α-phenylbenzyl)piperidino]butyrophenone (43076-30-8,76815-60-6)

Guidance literature:

With potassium carbonate; In butanone; Heating;

DOI:10.1016/0223-5234(93)90009-4

Reference yield: 69.0%

C18H21NO (115-46-8) + 4'-tert-butyl-4-chlorobutyrophenone (43076-61-5) → 4'-tert-butyl-4-[4-(α-hydroxy-α-phenylbenzyl)piperidino]butyrophenone (43076-30-8,76815-60-6)

Guidance literature:

With sodium carbonate; sodium iodide; In N,N-dimethyl-formamide; for 24h; Reflux;

DOI:10.1016/j.tet.2008.09.098

upstream raw materials:

C₁₈H₂₁NO

terfenadine

4'-tert-butyl-4-chlorobutyrophenone

tert-butylbenzene

Refernces

• 1、 -. "METHODS AND COMPOSITIONS FOR TREATING INFECTION". Paragraph 0205. . Retrieved 2015/09/28.
• 2、 El Ouarradi, Amane,Salard-Arnaud, Isabelle,Buisson, Didier. "Biooxidation of methyl group: application to the preparation of alcohol and acid metabolites of terfenadine, ebastine and analogues". experimental part. p. 11738 - 11744. Retrieved 2009/04/11.