5-Pyrimidinecarboxylic acid, 4-amino-2-methyl-, labeled with nitrogen-15 (9CI)

Base Information

• Chemical Name: 5-Pyrimidinecarboxylic acid, 4-amino-2-methyl-, labeled with nitrogen-15 (9CI)
• CAS No.: 41279-10-1
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.14
• Mol file: 41279-10-1.mol

Synonyms:

Chemical Property of 5-Pyrimidinecarboxylic acid, 4-amino-2-methyl-, labeled with nitrogen-15 (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Pyrimidinecarboxylic acid, 4-amino-2-methyl-, labeled with nitrogen-15 (9CI)

There total 2 articles about 5-Pyrimidinecarboxylic acid, 4-amino-2-methyl-, labeled with nitrogen-15 (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-4-amino-5-cyanopyrimidine (698-29-3) → 4-amino-2-methylpyrimidine-5-carboxylic acid (769-52-8,41279-10-1)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01867a055

Reference yield:

→ 4-amino-2-methylpyrimidine-5-carboxylic acid (769-52-8,41279-10-1)

Guidance literature:

2-methyl-4-amino-5-cyanopyrimidine (I) u. 10percent KOH;

DOI:10.1007/BF02145858

Reference yield:

4-amino-2-methylpyrimidine-5-carboxylic acid (769-52-8,41279-10-1) → 5-(5-(sec-butylthio)-1,3,4-thiadiazole-2-yl)-2-methylpyrimidin-4-amine

Guidance literature:

Multi-step reaction with 5 steps

1.1: sulfuric acid

2.1: hydrazine hydrate / ethanol

3.1: potassium hydroxide / ethanol / 0.5 h / Cooling with ice

3.2: Cooling with ice

4.1: sulfuric acid / 0 °C

5.1: sodium hydroxide / water / 0.33 h / 20 °C

5.2: 8 h / 20 °C

With sulfuric acid; hydrazine hydrate; potassium hydroxide; sodium hydroxide; In ethanol; water;

DOI:10.1002/jhet.2435

upstream raw materials:

2-methyl-4-amino-5-cyanopyrimidine

Downstream raw materials:

sulphamerazine

4-nitro-benzenesulfonic acid-(2-methyl-pyrimidin-4-ylamide)

Refernces

• 1、 Price et al.. "-". . p. 2818. Retrieved 1940.
• 2、 Wu, Wen-Neng,Tai, An-Qi,Chen, Qin,Ouyang, Gui-Ping. "Synthesis and Antiviral Bioactivity of Novel 2-Substituted Methlthio-5-(4-Amino-2-Methylpyrimidin-5-yl)-1,3,4-Thiadiazole Derivatives". . p. 626 - 632. Retrieved 2016/04/19.