N-(2,6-dimethylphenyl)pyridine-3-carboxamide

Base Information

• Chemical Name: N-(2,6-dimethylphenyl)pyridine-3-carboxamide
• CAS No.: 84951-65-5
• Molecular Formula: C₁₄H₁₄N₂O
• Molecular Weight: 226.278
• DSSTox Substance ID: DTXSID001329641
• ChEMBL ID: CHEMBL1547836
• Mol file: 84951-65-5.mol

Synonyms:N-(2,6-dimethylphenyl)pyridine-3-carboxamide;N-(2,6-Dimethyl-phenyl)-nicotinamide;MLS001204778;N-(2,6-dimethylphenyl)nicotinamide;SMR000514382;Oprea1_324344;Oprea1_840149;cid_767628;CHEMBL1547836;SCHEMBL10473593;BDBM64053;DTXSID001329641;HMS2847A08;STK005174;AKOS000670893;84951-65-5;N-(2,6-dimethylphenyl)-3-pyridinecarboxamide;AB00081981-01;AK-968/11163040;SR-01000430398;SR-01000430398-1

Chemical Property of N-(2,6-dimethylphenyl)pyridine-3-carboxamide

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 226.110613074
• Heavy Atom Count: 17
• Complexity: 257

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C(=CC=C1)C)NC(=O)C2=CN=CC=C2

Technology Process of N-(2,6-dimethylphenyl)pyridine-3-carboxamide

There total 2 articles about N-(2,6-dimethylphenyl)pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nicotinic acid (59-67-6) + 2,6-dimethylaniline (87-62-7) → Nicotinsaeure-(2,6-dimethyl-anilid) (84951-65-5)

Guidance literature:

With 1,4-dioxane; chloroformic acid ethyl ester; triethylamine;

DOI:10.1002/hlca.19590420430

Reference yield:

→ Nicotinsaeure-(2,6-dimethyl-anilid) (84951-65-5)

Guidance literature:

Pyridin-3-carbonsaeure, 2,6-Dimethyl-anilin, POCl3, sd. Toluol;

Reference yield:

Nicotinsaeure-(2,6-dimethyl-anilid) (84951-65-5) → 1-methyl-piperidine-3-carboxylic acid-(2,6-dimethyl-anilide) (132752-31-9)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol

2: ethanol; AgCl

3: platinum; acetic acid / Hydrogenation

With ethanol; acetic acid; platinum; silver(I) chloride;

DOI:10.1002/hlca.19590420430

upstream raw materials:

nicotinic acid

2,6-dimethylaniline

Downstream raw materials:

3-(2,6-dimethyl-phenylcarbamoyl)-1-methyl-pyridinium; iodide

1-methyl-piperidine-3-carboxylic acid-(2,6-dimethyl-anilide)