N,N-Diethyl-3-piperidinecarboxamide hydrochloride

Base Information

• Chemical Name: N,N-Diethyl-3-piperidinecarboxamide hydrochloride
• CAS No.: 859996-19-3
• Molecular Formula: C₁₀H₂₀N₂O*ClH
• Molecular Weight: 220.743
• NSC Number: 47355
• UNII: UP4WK7F7A6
• Mol file: 859996-19-3.mol

Synonyms:859996-19-3;N,N-DIETHYL-3-PIPERIDINECARBOXAMIDE HYDROCHLORIDE;N,N-diethylpiperidine-3-carboxamide hydrochloride;N,N-diethylpiperidine-3-carboxamide;hydrochloride;UP4WK7F7A6;NSC47355;NSC-47355;AKOS015847094;N,N-Diethylpiperidine-3-carboxamide HCl;Nipecotamide, N,N-diethyl-, hydrochloride;CS-0298093;EN300-235045;F2145-0677;3-Piperidinecarboxamide, N,N-diethyl-, hydrochloride (1:1)

Chemical Property of N,N-Diethyl-3-piperidinecarboxamide hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 220.1342410
• Heavy Atom Count: 14
• Complexity: 166

Purity/Quality:

98%min ^*data from raw suppliers

N,N-Diethyl-3-piperidinecarboxamide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCN(CC)C(=O)C1CCCNC1.Cl

Technology Process of N,N-Diethyl-3-piperidinecarboxamide hydrochloride

There total 4 articles about N,N-Diethyl-3-piperidinecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N,N-diethylnicotinamide (59-26-7) → N,N-diethyl-3-piperidinecarboxamide hydrochloride (859996-19-3)

Guidance literature:

With 1,1,2-trichloroethane; palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 46h; under 760.051 Torr;

DOI:10.1016/j.tet.2009.08.011

Reference yield:

C15H28N2O3 (937724-75-9) → N,N-diethyl-3-piperidinecarboxamide hydrochloride (859996-19-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2007.01.094

Reference yield:

N-(tert-butyloxycarbonyl)nipecotic acid (71381-75-4,88495-54-9,84358-12-3) → N,N-diethyl-3-piperidinecarboxamide hydrochloride (859996-19-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide*HCl; 1-hydroxybenzotriazole / CH₂Cl₂ / 20 °C

2: HCl / dioxane

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2007.01.094

upstream raw materials:

C₁₅H₂₈N₂O₃

N-(tert-butyloxycarbonyl)nipecotic acid

nipecotic acid

N,N-diethylnicotinamide