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Nikethamide

Base Information Edit
  • Chemical Name:Nikethamide
  • CAS No.:59-26-7
  • Molecular Formula:C10H14 N2 O
  • Molecular Weight:178.234
  • Hs Code.:29333999
  • European Community (EC) Number:200-418-5
  • NSC Number:760377,169863,130820,62103
  • UN Number:2810
  • UNII:368IVD6M32
  • DSSTox Substance ID:DTXSID9046524
  • Nikkaji Number:J5.179I
  • Wikipedia:Nikethamide
  • Wikidata:Q902548
  • NCI Thesaurus Code:C76625
  • Metabolomics Workbench ID:154444
  • ChEMBL ID:CHEMBL2104607
  • Mol file:59-26-7.mol
Nikethamide

Synonyms:Coramin;Coramine;Cordiamine;Corethamid;Diethylamide, Nicotinic;Diethylnicotinamid;Nicethamide;Nicotinic Diethylamide;Nikethamide;Nizethamid

Suppliers and Price of Nikethamide
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • N,N-Diethylnicotinamide
  • 2.5g
  • $ 403.00
  • TRC
  • N,N-Diethylnicotinamide(Nikethamide)
  • 2.5g
  • $ 135.00
  • Sigma-Aldrich
  • N,N-Diethylnicotinamide 99%
  • 25g
  • $ 32.30
  • Sigma-Aldrich
  • N,N-Diethylnicotinamide 99%
  • 100g
  • $ 86.60
  • Sigma-Aldrich
  • Nikethamide European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
  • Sigma-Aldrich
  • Nikethamide European Pharmacopoeia (EP) Reference Standard
  • n0800000
  • $ 190.00
  • Sigma-Aldrich
  • N,N-Diethylnicotinamide 99%
  • 500g
  • $ 392.00
  • Medical Isotopes, Inc.
  • N,N-Diethylnicotinamide(Nikethamide)
  • 2.5 g
  • $ 610.00
  • Biosynth Carbosynth
  • N,N-Diethylnicotinamide
  • 50 g
  • $ 50.00
  • Biosynth Carbosynth
  • N,N-Diethylnicotinamide
  • 100 g
  • $ 90.00
Total 141 raw suppliers
Chemical Property of Nikethamide Edit
Chemical Property:
  • Appearance/Colour:clear colorless to yellow liquid 
  • Vapor Pressure:0.0013mmHg at 25°C 
  • Melting Point:24-26 
  • Refractive Index:n20/D 1.524(lit.)  
  • Boiling Point:296-300 
  • PKA:pKa 3.46(H2O,t =20) (Uncertain) 
  • Flash Point:141.1°C 
  • PSA:33.20000 
  • Density:1.06 
  • LogP:1.56360 
  • Storage Temp.:2-8°C 
  • Water Solubility.:>=10 g/100 mL at 23 C 
  • XLogP3:0.3
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:2
  • Rotatable Bond Count:3
  • Exact Mass:178.110613074
  • Heavy Atom Count:13
  • Complexity:166
  • Transport DOT Label:Poison
Purity/Quality:

99% *data from raw suppliers

N,N-Diethylnicotinamide *data from reagent suppliers

Safty Information:
  • Pictogram(s):
  • Hazard Codes:
  • Statements: 25-36/37/38-23/24/25 
  • Safety Statements: 26-45-36/37/39 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CCN(CC)C(=O)C1=CN=CC=C1
  • Recent ClinicalTrials:Effects of Nebivolol on Subclinical Left Ventricular dySfunction: A Comparative Study Against Metoprolol
  • Description A further Corydalis alkaloid, coramine has been obtained from C. pseudoadunca M. Pop. It forms colourless needles from EtOH and is optically active with a specific rotation of [α]D - 391 ° (c 0.2, MeOH). Both the hydrochloride, m.p. 216-9°C and the hydrobromide, m.p. 223-6°C have been described.
  • Uses N,N-Diethylnicotinamide (DENC) is commonly used as a ligand to prepare tetranuclear copper complexes.
Technology Process of Nikethamide

There total 39 articles about Nikethamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether; In toluene; at 105 ℃; for 12h; under 3000.3 Torr;
DOI:10.1021/cs400232b
Guidance literature:
With hydrogenchloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In 1,4-dioxane; at 120 ℃; for 33h;
DOI:10.1055/s-0035-1561427
Guidance literature:
With (4,4′-di-tert-butyl-2,2′-bipyridine)bis[(2-pyridinyl)phenyl]iridium(III) hexafluorophosphate; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate; In acetonitrile; at 20 ℃; for 2.5h; chemoselective reaction; Inert atmosphere; Irradiation;
DOI:10.1021/acs.joc.0c02805
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