2,5-dioxopyrrolidin-1-yl 4-azidobutanoate

Base Information

• Chemical Name: 2,5-dioxopyrrolidin-1-yl 4-azidobutanoate
• CAS No.: 943858-70-6
• Molecular Formula: C₈H₁₀N₄O₄
• Molecular Weight: 226.192
• Mol file: 943858-70-6.mol

Synonyms:

Chemical Property of 2,5-dioxopyrrolidin-1-yl 4-azidobutanoate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

4-Azidobutyrate-N-hydroxysuccinimideEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Azidobutyric acid NHS ester has an azide and NHS ester end group. The azide can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. The NHS ester can react with amine groups to form stable amide bonds.
• Uses: 4-Azidobutyrate-N-hydroxysuccinimide ester is used in the synthesis of dual-cyclic RGD peptides as drug carrier αvβ3 integrin targeting.

Technology Process of 2,5-dioxopyrrolidin-1-yl 4-azidobutanoate

There total 1 articles about 2,5-dioxopyrrolidin-1-yl 4-azidobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 4-azidobutanoic acid (54447-68-6) → 2,5-dioxopyrrolidin-1-yl 4-azidobutanoate (943858-70-6)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1021/jacs.0c05537

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

4-azidobutanoic acid