4-(2-pyridinedisulfide)-4-methylvaleric acid succinimide ester

Base Information

• Chemical Name: 4-(2-pyridinedisulfide)-4-methylvaleric acid succinimide ester
• CAS No.: 890409-85-5
• Molecular Formula: C₁₅H₁₈N₂O₄S₂
• Molecular Weight: 354.451
• Mol file: 890409-85-5.mol

Synonyms:

Chemical Property of 4-(2-pyridinedisulfide)-4-methylvaleric acid succinimide ester

Chemical Property:

• Boiling Point: 487.8±55.0 °C(Predicted)
• Density: 1.36±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid N-Hydroxy succinimide ester 90+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-pyridinedisulfide)-4-methylvaleric acid succinimide ester

There total 4 articles about 4-(2-pyridinedisulfide)-4-methylvaleric acid succinimide ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 4-(2-pyridylldisulfanyl)-4-methylvaleric acid → 4-(2-pyridinedisulfide)-4-methylvaleric acid succinimide ester (890409-85-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

Reference yield:

2,2'-dipyridyldisulphide (2127-03-9) + 4-mercapto-4-dimethylpentanoic acid (140231-31-8) → 4-(2-pyridinedisulfide)-4-methylvaleric acid succinimide ester (890409-85-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium phosphate / methanol / 6 h / pH 7.5

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium phosphate; In methanol; dichloromethane;

Reference yield:

2,2'-dipyridyldisulphide (2127-03-9) → 4-(2-pyridinedisulfide)-4-methylvaleric acid succinimide ester (890409-85-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; aq. phosphate buffer / 6 h / pH 7.5

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; aq. phosphate buffer; dichloromethane;

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

2,2'-dipyridyldisulphide

4-mercapto-4-dimethylpentanoic acid