(S)-Ibrutinib

Base Information

Chemical Name:(S)-Ibrutinib
CAS No.:936563-97-2
Molecular Formula:C₂₅H₂₄N₆O₂
Molecular Weight:440.505
Hs Code.:
Mol file:936563-97-2.mol

Synonyms:

Suppliers and Price of (S)-Ibrutinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-Ibrutinib
5mg
$ 185.00

TRC
(S)-Ibrutinib-d5
10mg
$ 1540.00

Medical Isotopes, Inc.
(S)-Ibrutinib-d5
1 mg
$ 675.00

Total 16 raw suppliers

Chemical Property of (S)-Ibrutinib

Chemical Property:

Melting Point:88-95°C
Boiling Point:715.0±60.0 °C(Predicted)
PKA:4.09±0.30(Predicted)
Density:1.34±0.1 g/cm3(Predicted)
Storage Temp.:Amber Vial, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), DMSO (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

(S)-Ibrutinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (S)-Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor. (S)-Ibrutinib-d5 is the labeled analogue of (S)-Ibrutinib (I124975). (S)-Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.

Technology Process of (S)-Ibrutinib

There total 116 articles about (S)-Ibrutinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1022150-12-4
(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine

: 814-68-6,25189-84-8
acryloyl chloride

: 936563-87-0,936563-96-1,936563-97-2
ibrutinib

Guidance literature:: With sodium hydrogencarbonate; In 2-methyltetrahydrofuran; at -5 - 0 ℃; for 1h; Inert atmosphere;

Reference yield: 95.0%

: 1553977-42-6,1642571-07-0
3-(4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3.4-d]pyrimidin-4-amine hydrochloride salt

: 814-68-6,25189-84-8
acryloyl chloride

: 936563-87-0,936563-96-1,936563-97-2
ibrutinib

Guidance literature:: With sodium hydrogencarbonate; In 2-methyltetrahydrofuran; at -5 - 0 ℃; for 1h; Inert atmosphere;

Reference yield: 93.4%

: 1022150-11-3
(3R)‐4‐amino‐3‐(4-phenoxyphenyl)‐1‐(1‐tert-butoxycarbonylpiperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine

: 814-68-6,25189-84-8
acryloyl chloride

: 936563-87-0,936563-96-1,936563-97-2
ibrutinib

Guidance literature:: (3R)‐4‐amino‐3‐(4-phenoxyphenyl)‐1‐(1‐tert-butoxycarbonylpiperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine; With triethylamine; In ethyl acetate; Industrial scale;

acryloyl chloride; In tetrahydrofuran; ethyl acetate; at 20 ℃; Solvent; Industrial scale;