ADAMTS-5

Base Information

• Chemical Name: ADAMTS-5
• CAS No.: 929634-33-3
• Molecular Formula: C₁₆H₁₁ClF₃N₃OS₃
• Molecular Weight: 449.929
• Mol file: 929634-33-3.mol

Synonyms:

Chemical Property of ADAMTS-5

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

ADAMTS-5Inhibitor ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 and has the potential of inhibiting the degredation of aggrecan, a major component of cartilage lost in osteoporosis.

Technology Process of ADAMTS-5

There total 3 articles about ADAMTS-5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde (128455-62-9) → 5-[5-(4-chloro-benzylsulfanyl)-1-methyl-3-trifluoromethyl-1H-pyrazol-4-ylmethylene]-2-thioxo-thiazolidin-4-one (929634-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / dimethylsulfoxide / 12 h / 40 °C

2: β-alanine; acetic acid / 12 h / 110 °C

With acetic acid; triethylamine; 3-amino propanoic acid; In dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2006.12.020

Reference yield:

(4-chlorophenyl)methanethiol (6258-66-8) → 5-[5-(4-chloro-benzylsulfanyl)-1-methyl-3-trifluoromethyl-1H-pyrazol-4-ylmethylene]-2-thioxo-thiazolidin-4-one (929634-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / dimethylsulfoxide / 12 h / 40 °C

2: β-alanine; acetic acid / 12 h / 110 °C

With acetic acid; triethylamine; 3-amino propanoic acid; In dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2006.12.020

Reference yield:

5-(4-chloro-benzylsulfanyl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carbaldehyde + 2-thioxo-4-thiazolidinone (141-84-4) → 5-[5-(4-chloro-benzylsulfanyl)-1-methyl-3-trifluoromethyl-1H-pyrazol-4-ylmethylene]-2-thioxo-thiazolidin-4-one (929634-33-3)

Guidance literature:

With acetic acid; 3-amino propanoic acid; at 110 ℃; for 12h;

DOI:10.1016/j.bmcl.2006.12.020

upstream raw materials:

2-thioxo-4-thiazolidinone

5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde

(4-chlorophenyl)methanethiol

Refernces