acetate of 2-monobromestrone

Base Information

Chemical Name:acetate of 2-monobromestrone
CAS No.:94758-07-3
Molecular Formula:C₂₀H₂₃BrO₃
Molecular Weight:391.305
Hs Code.:

Synonyms:

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Chemical Property of acetate of 2-monobromestrone

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Technology Process of acetate of 2-monobromestrone

There total 1 articles about acetate of 2-monobromestrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53-16-7
Estrone

: 108-24-7
acetic anhydride

: 901-93-9
estrone acetate

: 94758-07-3
acetate of 2-monobromestrone

: 95733-63-4
acetate of 4,16-dibromoestrone

: 95784-01-3
acetate of 2,16-dibromoestrone

Guidance literature:: With pyridine; bromine; Yield given. Multistep reaction. Further byproducts given; 1) CH₂Cl₂, 60 min., 2) room temperature;
DOI:10.1007/BF00575753

Reference yield:

: 94758-07-3
acetate of 2-monobromestrone

: 2-bromo-17β-(3'-trifluoromethylbenzenesulfonamido)-1,3,5(10)-estratrien-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; potassium carbonate / 3 h / Reflux

2: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

3: 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 35 °C / Inert atmosphere

4: pyridine / dichloromethane / 16.2 h / 0 - 20 °C

With pyridine; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2015.07.019