(2R)-N-({5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorophenyl}sulfonyl)-2-hydroxypropanimidamide

Base Information

Chemical Name:(2R)-N-({5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorophenyl}sulfonyl)-2-hydroxypropanimidamide
CAS No.:912587-25-8
Molecular Formula:C₂₅H₁₉F₃N₄O₅S
Molecular Weight:544.511
Hs Code.:

(2R)-N-({5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorophenyl}sulfonyl)-2-hydroxypropanimidamide

Synonyms:

Suppliers and Price of (2R)-N-({5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorophenyl}sulfonyl)-2-hydroxypropanimidamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of (2R)-N-({5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorophenyl}sulfonyl)-2-hydroxypropanimidamide

Chemical Property:

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R)-N-({5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorophenyl}sulfonyl)-2-hydroxypropanimidamide

There total 4 articles about (2R)-N-({5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorophenyl}sulfonyl)-2-hydroxypropanimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorobenzenesulfonyl chloride

: 4024-05-9,1314999-69-3
(2R)-2-hydroxypropanimidamide hydrochloride

: 912587-25-8
(2R)-N-({5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorophenyl}sulfonyl)-2-hydroxypropanimidamide

Guidance literature:: (2R)-2-hydroxypropanimidamide hydrochloride; With 3,4-dihydro-2H-pyran; methanesulfonic acid; In 1-methyl-pyrrolidin-2-one; at 20 - 30 ℃; for 15h; Inert atmosphere;

With triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 15 - 30 ℃; for 0.25h;

5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorobenzenesulfonyl chloride; Solvent; Temperature; Time; Further stages;

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorobenzenesulfonyl chloride

: 4024-05-9,1314999-69-3
(2R)-2-hydroxypropanimidamide hydrochloride

: 912587-25-8
(2R)-N-({5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorophenyl}sulfonyl)-2-hydroxypropanimidamide

Guidance literature:: 3,4-dihydro-2H-pyran; (2R)-2-hydroxypropanimidamide hydrochloride; With methanesulfonic acid; In 1-methyl-pyrrolidin-2-one; at 20 - 30 ℃; for 15h; Inert atmosphere;

With triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 15 - 30 ℃; for 0.25h;

5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorobenzenesulfonyl chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 15 - 30 ℃; for 0.5h;

Reference yield:

: 35730-09-7
2,5-difluorobenzoyl chloride

: 912587-25-8
(2R)-N-({5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorophenyl}sulfonyl)-2-hydroxypropanimidamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 3 h / 50 - 70 °C / Inert atmosphere

1.2: 2 h / 20 - 70 °C

2.1: thionyl chloride / Isopropyl acetate; N,N-dimethyl-formamide / 3 h / 50 - 70 °C / Inert atmosphere

2.2: 3 h / 30 - 65 °C

3.1: methanesulfonic acid; 3,4-dihydro-2H-pyran / 1-methyl-pyrrolidin-2-one / 15 h / 20 - 30 °C / Inert atmosphere

3.2: 0.25 h / 15 - 30 °C

With 3,4-dihydro-2H-pyran; thionyl chloride; methanesulfonic acid; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; Isopropyl acetate; N,N-dimethyl-formamide;