(R)-2-hydroxypropaniMidaMide hydrochloride

Base Information

• Chemical Name: (R)-2-hydroxypropaniMidaMide hydrochloride
• CAS No.: 4024-05-9
• Molecular Formula: C3H9ClN2O
• Molecular Weight: 124.56900
• Mol file: 4024-05-9.mol

Synonyms:X6061

Chemical Property of (R)-2-hydroxypropaniMidaMide hydrochloride

Chemical Property:

• PSA: 70.10000
• LogP: 0.90520
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

(2R)-2-HydroxypropanimidamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-hydroxypropaniMidaMide hydrochloride

There total 1 articles about (R)-2-hydroxypropaniMidaMide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-lactamide (598-81-2) → (2R)-2-hydroxypropanimidamide hydrochloride (4024-05-9,1314999-69-3)

Guidance literature:

With hydrogenchloride; nitrogen; ammonia; triethyloxonium fluoroborate; In tetrahydrofuran; methanol;

Reference yield:

5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorobenzenesulfonyl chloride + (2R)-2-hydroxypropanimidamide hydrochloride (4024-05-9,1314999-69-3) → (2R)-N-({5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorophenyl}sulfonyl)-2-hydroxypropanimidamide (912587-25-8)

Guidance literature:

(2R)-2-hydroxypropanimidamide hydrochloride; With 3,4-dihydro-2H-pyran; methanesulfonic acid; In 1-methyl-pyrrolidin-2-one; at 20 - 30 ℃; for 15h; Inert atmosphere;

With triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 15 - 30 ℃; for 0.25h;

5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorobenzenesulfonyl chloride; Solvent; Temperature; Time; Further stages;

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + 5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorobenzenesulfonyl chloride + (2R)-2-hydroxypropanimidamide hydrochloride (4024-05-9,1314999-69-3) → (2R)-N-({5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorophenyl}sulfonyl)-2-hydroxypropanimidamide (912587-25-8)

Guidance literature:

3,4-dihydro-2H-pyran; (2R)-2-hydroxypropanimidamide hydrochloride; With methanesulfonic acid; In 1-methyl-pyrrolidin-2-one; at 20 - 30 ℃; for 15h; Inert atmosphere;

With triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 15 - 30 ℃; for 0.25h;

5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorobenzenesulfonyl chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 15 - 30 ℃; for 0.5h;

upstream raw materials:

(R)-lactamide

Downstream raw materials:

(2R)-N-({5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzoimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorophenyl}sulfonyl)-2-hydroxypropanimidamide

Refernces