11-Fluoro-6-hydroxy-3,3,12-trimethylpyrano[2,3-c]acridin-7-one

Base Information

Chemical Name:11-Fluoro-6-hydroxy-3,3,12-trimethylpyrano[2,3-c]acridin-7-one
CAS No.:82260-83-1
Molecular Formula:C₁₉H₁₆FNO₃
Molecular Weight:325.339
Hs Code.:
NSC Number:342426
DSSTox Substance ID:DTXSID10419548
Wikidata:Q82230588

Synonyms:82260-83-1;NSC342426;DTXSID10419548;11-fluoro-6-hydroxy-3,3,12-trimethylpyrano[2,3-c]acridin-7-one;NSC-342426

Suppliers and Price of 11-Fluoro-6-hydroxy-3,3,12-trimethylpyrano[2,3-c]acridin-7-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 11-Fluoro-6-hydroxy-3,3,12-trimethylpyrano[2,3-c]acridin-7-one

Chemical Property:

Vapor Pressure:1.02E-11mmHg at 25°C
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:325.11142153
Heavy Atom Count:24
Complexity:563

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(C=CC2=C(O1)C=C(C3=C2N(C4=C(C3=O)C=CC=C4F)C)O)C

Technology Process of 11-Fluoro-6-hydroxy-3,3,12-trimethylpyrano[2,3-c]acridin-7-one

There total 4 articles about 11-Fluoro-6-hydroxy-3,3,12-trimethylpyrano[2,3-c]acridin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82260-64-8
5-fluoro-1,3-dimethoxyacridine-9-carboxylate de methyle

: 82260-83-1
11-fluoro-3,12-dihydro-6-hydroxy-3,3,12-trimethyl-7H-pyranno<2,3-c>acridin-7-one (11-fluoro-noracronycine)

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / benzene / Heating

2: 85 percent / K₃Fe(CN)6, 2.5N KOH / H₂O / 4 h / Heating

3: 92 percent / cc. HBr / Heating

4: 1.) K₂CO₃, KI; 2.) N,N-diethylaniline / 1.) DMF, 70 deg C, 48 h; 2.)reflux, 80 min

With potassium hydroxide; hydrogen bromide; potassium carbonate; N,N-diethylaniline; potassium iodide; potassium hexacyanoferrate(III); In water; benzene;
DOI:10.1002/bscb.19820910105

Reference yield:

: 82260-76-2
methosulfate de 5-fluoro-1,3-dimethoxy-9-methoxycarbonyl-10-methylacridinium

: 82260-83-1
11-fluoro-3,12-dihydro-6-hydroxy-3,3,12-trimethyl-7H-pyranno<2,3-c>acridin-7-one (11-fluoro-noracronycine)

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / K₃Fe(CN)6, 2.5N KOH / H₂O / 4 h / Heating

2: 92 percent / cc. HBr / Heating

3: 1.) K₂CO₃, KI; 2.) N,N-diethylaniline / 1.) DMF, 70 deg C, 48 h; 2.)reflux, 80 min

With potassium hydroxide; hydrogen bromide; potassium carbonate; N,N-diethylaniline; potassium iodide; potassium hexacyanoferrate(III); In water;
DOI:10.1002/bscb.19820910105

Reference yield:

: 82260-67-1
5-fluoro-1,3-dimethoxy-10-methyl-acridan-9-one

: 82260-83-1
11-fluoro-3,12-dihydro-6-hydroxy-3,3,12-trimethyl-7H-pyranno<2,3-c>acridin-7-one (11-fluoro-noracronycine)

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / cc. HBr / Heating

2: 1.) K₂CO₃, KI; 2.) N,N-diethylaniline / 1.) DMF, 70 deg C, 48 h; 2.)reflux, 80 min

With hydrogen bromide; potassium carbonate; N,N-diethylaniline; potassium iodide;
DOI:10.1002/bscb.19820910105