2,6-dibromo-N-methylpyridin-3-amine

Base Information

• Chemical Name: 2,6-dibromo-N-methylpyridin-3-amine
• CAS No.: 84539-50-4
• Molecular Formula: C₆H₆Br₂N₂
• Molecular Weight: 265.935
• DSSTox Substance ID: DTXSID401293129
• Mol file: 84539-50-4.mol

Synonyms:2,6-dibromo-N-methylpyridin-3-amine;84539-50-4;3-Pyridinamine, 2,6-dibromo-N-methyl-;N-(2,6-dibromopyridin-3-yl)-N-methylamine;DTXSID401293129;MFCD00234176;2,6-Dibromo-N-methyl-3-pyridinamine;SY311933;E84625;EN300-2967221;AC-907/25004523

Chemical Property of 2,6-dibromo-N-methylpyridin-3-amine

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 265.88772
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CNC1=C(N=C(C=C1)Br)Br

Technology Process of 2,6-dibromo-N-methylpyridin-3-amine

There total 4 articles about 2,6-dibromo-N-methylpyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

3-methylaminopyridine 1-oxide (54818-71-2) → (2,6-dibromo-[3]pyridyl)-methyl-amine (84539-50-4) + (2,6-Dibromo-1-oxy-pyridin-3-yl)-methyl-amine (84539-45-7) + Methyl-(2,4,6-tribromo-pyridin-3-yl)-amine (84539-51-5) + Methyl-(2,4,6-tribromo-1-oxy-pyridin-3-yl)-amine (84539-46-8)

Guidance literature:

With bromine; potassium carbonate; In tetrachloromethane; for 6h;

DOI:10.1021/jo00155a027

Reference yield:

N-methyl-N-(3-pyridyl)amine (18364-47-1) → (2,6-dibromo-[3]pyridyl)-methyl-amine (84539-50-4)

Guidance literature:

With bromine; acetic acid;

Reference yield:

3-Bromopyridine (626-55-1,163928-56-1) → (2,6-dibromo-[3]pyridyl)-methyl-amine (84539-50-4)

Guidance literature:

Multi-step reaction with 2 steps

1: CuSO₄

2: acetic acid; bromine

With bromine; copper(II) sulfate; acetic acid;

upstream raw materials:

N-methyl-N-(3-pyridyl)amine

3-methylaminopyridine 1-oxide

bromine

acetic acid