Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate

Base Information

Chemical Name:Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate
CAS No.:902589-96-2
Molecular Formula:C₁₇H₂₂N₄O₄S
Molecular Weight:378.452
Hs Code.:
Mol file:902589-96-2.mol

Synonyms:

Suppliers and Price of Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
YMU1
1mg
$ 50.00

TRC
YMU1
5mg
$ 185.00

Sigma-Aldrich
YMU1 ≥98% (HPLC)
25mg
$ 400.00

Sigma-Aldrich
Thymidylate Kinase Inhibitor, YMU1
10mg
$ 124.00

Sigma-Aldrich
YMU1 ≥98% (HPLC)
5mg
$ 99.20

DC Chemicals
YMU1 >98%
1 g
$ 1800.00

DC Chemicals
YMU1 >98%
250 mg
$ 900.00

DC Chemicals
YMU1 >98%
100 mg
$ 550.00

Cayman Chemical
YMU1
10mg
$ 119.00

Cayman Chemical
YMU1
5mg
$ 75.00

Total 9 raw suppliers

Chemical Property of Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate

Chemical Property:

Storage Temp.:2-8°C
Solubility.:DMSO: soluble1mg/mL, clear (warmed)

Purity/Quality:

97% ^*data from raw suppliers

YMU1 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses YMU1 is a potent, reversible, and ATP-competitive inhibitor of human Thymidylate kinase (TMPK).

Technology Process of Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate

There total 9 articles about Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1380297-26-6
ethyl 4-(2-iodoacetyl)piperazine-1-carboxylate

: 60750-75-6
4,6-dimethylisothiazolo[5,4-b]pyridin-3(2H)-one

: ethyl 4-(2-(4,6-dimethylisothiazolo[5,4-b]pyndin-3-yloxy)acetyl)piperazine-1-carboxylate

: 902589-96-2
YMU-1

Guidance literature:: With caesium carbonate; triethylamine; In dichloromethane; at 20 ℃; for 24h; Product distribution / selectivity;

Reference yield:

: 120-43-4
4-ethoxycarbonylpiperazine

: 219563-96-9
(4,6-Dimethyl-3-oxo-2,3-dihydroisothiazolo<5,4-b>pyridin-2-yl)acetic acid

: 902589-96-2
YMU-1

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 27 ℃; for 16h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 54585-47-6
3-cyano-4,6-dimethyl-2-mercaptopyridine

: 902589-96-2
YMU-1

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 4 h / 100 °C

1.2: pH 5 - 6

2.1: N-ethyl-N,N-diisopropylamine; caesium carbonate / dichloromethane / 5 h / 20 °C

3.1: hydrogenchloride; water / 5 h / 100 °C

4.1: dmap; N-ethyl-N,N-diisopropylamine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 16 h / 27 °C / Inert atmosphere

With hydrogenchloride; dmap; sulfuric acid; water; caesium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane;