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60750-75-6

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60750-75-6 Usage

Description

4,6-dimethyl[1,2]thiazolo[5,4-b]pyridin-3(2H)-one, also known as Zolpidem, is a nonbenzodiazepine hypnotic medication primarily used for the short-term treatment of insomnia. It works by affecting certain chemicals in the brain that may be unbalanced in people with insomnia, helping to improve sleep onset and maintenance.
Used in Pharmaceutical Industry:
4,6-dimethyl[1,2]thiazolo[5,4-b]pyridin-3(2H)-one is used as a sleep aid for the short-term treatment of insomnia. It is effective in improving sleep onset and maintenance, making it a popular choice for individuals struggling with insomnia.
Used in Medical Treatments:
4,6-dimethyl[1,2]thiazolo[5,4-b]pyridin-3(2H)-one is used as a medication to help individuals with insomnia achieve better sleep quality. It is typically taken orally and its effects can be felt within 30 minutes of ingestion.
However, it is important to note that 4,6-dimethyl[1,2]thiazolo[5,4-b]pyridin-3(2H)-one carries the risk of dependence, tolerance, and potential side effects. Therefore, it should be used with caution and according to a doctor's instructions. It is commonly sold under the brand name Ambien and is available in immediate-release and extended-release forms.

Check Digit Verification of cas no

The CAS Registry Mumber 60750-75-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,7,5 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 60750-75:
(7*6)+(6*0)+(5*7)+(4*5)+(3*0)+(2*7)+(1*5)=116
116 % 10 = 6
So 60750-75-6 is a valid CAS Registry Number.

60750-75-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,6-Dimethylisothiazolo[5,4-b]pyridin-3(2H)-one

1.2 Other means of identification

Product number -
Other names 4,6-dimethyl-[1,2]thiazolo[5,4-b]pyridin-3-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:60750-75-6 SDS

60750-75-6Relevant articles and documents

Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-Induced Degradation

Chen, Yi-Hsuan,Hsu, Hua-Yi,Yeh, Ming-Tyng,Chen, Chen-Cheng,Huang, Chang-Yu,Chung, Ying-Hsuan,Chang, Zee-Fen,Kuo, Wei-Chen,Chan, Nei-Li,Weng, Jui-Hsia,Chung, Bon-Chu,Chen, Yu-Ju,Jian, Cheng-Bang,Shen, Ching-Chieh,Tai, Hwan-Ching,Sheu, Sheh-Yi,Fang, Jim-Min

, p. 9906 - 9918 (2016/11/19)

Targeting thymidylate kinase (TMPK) that catalyzes the phosphotransfer reaction for formation of dTDP from dTMP is a new strategy for anticancer treatment. This study is to understand the inhibitory mechanism of a previously identified human TMPK (hTMPK) inhibitor YMU1 (1a) by molecular docking, isothermal titration calorimetry, and photoaffinity labeling. The molecular dynamics simulation suggests that 1a prefers binding at the catalytic site of hTMPK, whereas the hTMPK inhibitors that bear pyridino[d]isothiazolone or benzo[d]isothiazolone core structure in lieu of the dimethylpyridine-fused isothiazolone moiety in 1a can have access to both the ATP-binding and catalytic sites. The binding sites of hTMPK inhibitors were validated by photoaffinity labeling and mass spectrometric studies. Taking together, 1a and its analogues stabilize the conformation of ligand-induced degradation (LID) region of hTMPK and block the catalytic site or ATP-binding site, thus attenuating the ATP binding-induced closed conformation that is required for phosphorylation of dTMP.

Synthesis and anorectic activity of 2H-4,6-dimethyl-2-[(4-phenylpiperazin-1-yl)methyl]-3-oxo-2,3 -dihydroisothiazolo[5,4-b]pyridine

Malinka,Rutkowska

, p. 595 - 601 (2007/10/03)

The synthesis of 2H-4,6-dimethyl-2-[(4-phenylpiperazin-1-yl)methyl]-3-oxo-2,3 -dihydroisothiazolo[5,4-b]pyridine (3) and its biological properties are described. Compound 3 pharmacologically evaluated in vivo by use of behavioral tests showed to have a profile of activity characteristic of stimulation of the central serotoninergic system, mostly 5-HT(2A) receptors (anorectic action: 2 mg/kg ip, 8.5 mg/kg po). However, receptor activity of isothiazolopyridine 3 was not confirmed in vitro using 5-HT(2A) and 5-HT(1A) receptor binding technique. Molecular modeling studies demonstrated that it is difficult to predict bioactive conformation of title molecule 3.

Synthesis and properties of some derivatives of 2H-4,6-dimethylpyrido[3,2-d]isothiazolin-3-one

Zawisza,Malinka

, p. 124 - 132 (2007/10/02)

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