6-cyclopropyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

Base Information

Chemical Name:6-cyclopropyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS No.:937597-47-2
Molecular Formula:C₁₃H₁₅N₃O₂
Molecular Weight:245.281
Hs Code.:
European Community (EC) Number:877-384-9
Mol file:937597-47-2.mol

Synonyms:6-cyclopropyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid;937597-47-2;6-Cyclopropyl-1-propyl-pyrazolo[3,4-b]pyridine-4-carboxylic acid;6-cyclopropyl-1-propylpyrazolo[3,4-b]pyridine-4-carboxylic acid;SCHEMBL1695118;AMFWYYBVTMGMSH-UHFFFAOYSA-N;BBL040587;MFCD08558139;STK350735;AKOS000313544;DB-428705;CS-0264494;EN300-92893

Suppliers and Price of 6-cyclopropyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-cyclopropyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

Chemical Property:

Boiling Point:426.5±45.0 °C(Predicted)
PKA:1.13±0.30(Predicted)
Density:1.44±0.1 g/cm3(Predicted)
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:245.116426730
Heavy Atom Count:18
Complexity:332

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCCN1C2=C(C=N1)C(=CC(=N2)C3CC3)C(=O)O

Technology Process of 6-cyclopropyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

There total 4 articles about 6-cyclopropyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 937597-47-2
6-cyclopropyl-1-propyl-1-pyrazolo[3,4-b]pyridine-4-carboxylic acid

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 0.25h;

In N,N-dimethyl-formamide; at 20 ℃; for 2h;

With water; sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield: 35.0%

: C₁₅H₁₉N₃O₂

: 937597-47-2
6-cyclopropyl-1-propyl-1-pyrazolo[3,4-b]pyridine-4-carboxylic acid

Guidance literature:: With potassium hydroxide; In isopropyl alcohol; at 20 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.1c00758

Reference yield:

: 21080-80-8
ethyl 4-cyclopropyl-2,4-dioxobutanoate

: 937597-47-2
6-cyclopropyl-1-propyl-1-pyrazolo[3,4-b]pyridine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 5 h / Reflux

2: potassium hydroxide / isopropyl alcohol / 20 °C / Inert atmosphere

With acetic acid; potassium hydroxide; In isopropyl alcohol;
DOI:10.1021/acs.jmedchem.1c00758