3-(propan-2-yl)[1]benzofuro[3,2-g]cinnolin-4-amine

Base Information

• Chemical Name: 3-(propan-2-yl)[1]benzofuro[3,2-g]cinnolin-4-amine
• CAS No.: 76795-58-9
• Molecular Formula: C₁₇H₁₅N₃O
• Molecular Weight: 277.326
• Mol file: 76795-58-9.mol

Synonyms:

Chemical Property of 3-(propan-2-yl)[1]benzofuro[3,2-g]cinnolin-4-amine

Chemical Property:

• Vapor Pressure: 2.66E-10mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(propan-2-yl)[1]benzofuro[3,2-g]cinnolin-4-amine

There total 5 articles about 3-(propan-2-yl)[1]benzofuro[3,2-g]cinnolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

Z-2-(2-dibenzofuranylhydrazono)-isovaleronitrile (76795-47-6) → 7-Isopropyl-11-oxa-8,9-diaza-benzo[b]fluoren-6-ylamine (76795-58-9)

Guidance literature:

With aluminium trichloride; In toluene; for 3h; Heating;

DOI:10.1002/jhet.5570170607

Reference yield:

3-nitrodibenzofuran (5410-97-9) → 7-Isopropyl-11-oxa-8,9-diaza-benzo[b]fluoren-6-ylamine (76795-58-9)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / Raney Ni / 80 °C / 22800 Torr

2: NaNO₂, 1 N HCl / H₂O / 1 h / Ambient temperature

3: 60 percent / sodium acetate / aq. ethanol / 3 h / 0 °C

4: 60 percent / 40percent NaOH / dioxane; H₂O / 1 h / Ambient temperature

5: 60 percent / AlCl₃ / toluene / 3 h / Heating

With hydrogenchloride; sodium hydroxide; aluminium trichloride; hydrogen; sodium acetate; sodium nitrite; nickel; In 1,4-dioxane; ethanol; water; toluene;

DOI:10.1002/jhet.5570170607

Reference yield:

3-aminodibenzofuran (4106-66-5) → 7-Isopropyl-11-oxa-8,9-diaza-benzo[b]fluoren-6-ylamine (76795-58-9)

Guidance literature:

Multi-step reaction with 4 steps

1: NaNO₂, 1 N HCl / H₂O / 1 h / Ambient temperature

2: 60 percent / sodium acetate / aq. ethanol / 3 h / 0 °C

3: 60 percent / 40percent NaOH / dioxane; H₂O / 1 h / Ambient temperature

4: 60 percent / AlCl₃ / toluene / 3 h / Heating

With hydrogenchloride; sodium hydroxide; aluminium trichloride; sodium acetate; sodium nitrite; In 1,4-dioxane; ethanol; water; toluene;

DOI:10.1002/jhet.5570170607

upstream raw materials:

Z-2-(2-dibenzofuranylhydrazono)-isovaleronitrile

3-aminodibenzofuran

3-nitrodibenzofuran

ethyl (2-dibenzofuranyl)azoisopropylcyanoacetate