4106-66-5 Usage
Uses
Used in Pharmaceutical Industry:
3-Aminodibenzofuran is used as a building block for the preparation of dibenzofuryl(phosphonomethyl)alanines, which are known as endothelin converting enzyme (ECE) inhibitors. These inhibitors play a crucial role in the regulation of vascular tone and blood pressure, making them potential therapeutic agents for the treatment of various cardiovascular diseases and conditions related to the renin-angiotensin system.
As a reactant in the synthesis of ECE inhibitors, 3-aminodibenzofuran contributes to the development of novel pharmaceutical compounds that can help in the management and treatment of hypertension, heart failure, and other related cardiovascular disorders. 3-AMINODIBENZOFURAN's unique structure and reactivity make it a valuable component in the design and synthesis of new drugs with improved efficacy and selectivity.
Reactions
Synthesis of Schiff baseEthanolic solutions of 3-aminodibenzofuran and 2-furan carboxaldehyde in 1:1 molar ratio were mixed and refluxed over a water-bath for 3 hours. The resulting Schiff base that separated out on cooling the mixture was filtered, washed with ethanol and air-dried.
Check Digit Verification of cas no
The CAS Registry Mumber 4106-66-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,1,0 and 6 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4106-66:
(6*4)+(5*1)+(4*0)+(3*6)+(2*6)+(1*6)=65
65 % 10 = 5
So 4106-66-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H9NO/c13-8-5-6-10-9-3-1-2-4-11(9)14-12(10)7-8/h1-7H,13H2
4106-66-5Relevant academic research and scientific papers
Cu(II)-Mediated N-H and N-Alkyl Aryl Amination and Olefin Aziridination
Munnuri, Sailu,Anugu, Raghunath Reddy,Falck, John R.
supporting information, p. 1926 - 1929 (2019/03/11)
Cu(II)-mediated direct NH2 and NH alkyl aryl aminations and olefin aziridinations are described. These room-temperature, one-pot, environmentally friendly procedures replace costly Rh2 catalysts and, in some instances, display important differences with comparable Rh2- and Fe-supported reactions.
