Caffeic anhydride

Base Information

• Chemical Name: Caffeic anhydride
• CAS No.: 854237-32-4
• Molecular Formula: C₁₈H₁₄O₇
• Molecular Weight: 342.305
• Mol file: 854237-32-4.mol

Synonyms:

Chemical Property of Caffeic anhydride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Caffeicanhydride ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Caffeic anhydride

There total 2 articles about Caffeic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

caffeic acid (331-39-5,501-16-6) → (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic anhydride (854237-32-4)

Guidance literature:

caffeic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 25 ℃; for 2h; Inert atmosphere;

With pyridine; In toluene; at 25 ℃; Inert atmosphere;

DOI:10.1016/j.bioorg.2019.103058

Reference yield:

caffeic acid (331-39-5,501-16-6) → caffeic anhydride (945404-43-3,854237-32-4)

Guidance literature:

With diisopropyl-carbodiimide; In dimethyl sulfoxide;

DOI:10.1016/j.ejphar.2017.07.006

Reference yield:

caffeic anhydride (945404-43-3,854237-32-4) + DL-tryptophan methyl ester (7303-49-3) → methyl (E)-(3-(3,4-dihydroxyphenyl)acryloyl)tryptophanate

Guidance literature:

at 20 ℃; for 12h;

DOI:10.1016/j.ejphar.2017.07.006

upstream raw materials:

caffeic acid

caffeic acid

Refernces

• 1、 Park, Jae B.,Wang, Thomas T.Y.. "Methyl (E)-(3-(3,4-dihydroxyphenyl)acryloyl)tryptophanate can suppress MCP-1 expression by inhibiting p38 MAP kinase and NF-κB in LPS-stimulated differentiated THP-1 cells". . p. 149 - 155. Retrieved 2017/07/12.