4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[(2-methylpropan-2-yl)oxy]butanoic acid

Base Information

Chemical Name:4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[(2-methylpropan-2-yl)oxy]butanoic acid
CAS No.:905857-50-3
Molecular Formula:C₂₃H₂₇NO₅
Molecular Weight:397.471
Hs Code.:
European Community (EC) Number:860-569-3,868-242-7

Synonyms:905857-46-7;905857-50-3;4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[(2-methylpropan-2-yl)oxy]butanoic acid;4-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-2-[(2-methylpropan-2-yl)oxy]butanoic acid;FT-0652600;FT-0654765;A843589;A843590

Suppliers and Price of 4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[(2-methylpropan-2-yl)oxy]butanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(2R)-2-TERT-BUTYLOXY-4-(9-FLUORENNYLMETHOXY)-CARBONYLAMINOBUTYRIC ACID 95.00%
10G
$ 1334.03

Total 1 raw suppliers

Chemical Property of 4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[(2-methylpropan-2-yl)oxy]butanoic acid

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:397.18892296
Heavy Atom Count:29
Complexity:550

Purity/Quality:

99% ^*data from raw suppliers

(2R)-2-TERT-BUTYLOXY-4-(9-FLUORENNYLMETHOXY)-CARBONYLAMINOBUTYRIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(CCNC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)C(=O)O

Technology Process of 4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[(2-methylpropan-2-yl)oxy]butanoic acid

There total 4 articles about 4-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[(2-methylpropan-2-yl)oxy]butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 905857-47-8
(2R)-4-[(9-fluorenylmethoxy)carbonylamino]-2-hydroxybutyric acid

: 905857-50-3
(2R)-2-tert-butyloxy-4-(9-fluorenylmethoxy)carbonylaminobutyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 79.6 percent / sulfuric acid / CH₂Cl₂ / 40 h / 20 °C

2: N,N-diisopropylethylamine / dioxane / 0.83 h / 20 °C

3: aq. hydrochloric acid / 2 h / pH 5

With hydrogenchloride; sulfuric acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ja0580587

Reference yield:

: 905857-48-9
(2R)-2-tert-butyloxy-4-(9-fluorenylmethoxy)carbonylaminobutyrate tert-butyl ester

: 905857-50-3
(2R)-2-tert-butyloxy-4-(9-fluorenylmethoxy)carbonylaminobutyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-diisopropylethylamine / dioxane / 0.83 h / 20 °C

2: aq. hydrochloric acid / 2 h / pH 5

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;
DOI:10.1021/ja0580587

Reference yield:

: 102774-86-7
9-fluorenylmethyl N-succinimidyl carbonate

: 905857-50-3
(2R)-2-tert-butyloxy-4-(9-fluorenylmethoxy)carbonylaminobutyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 95.8 percent / NaHCO₃ / H₂O; 1,2-dimethoxy-ethane / 0.26 h / 20 °C

2: 79.6 percent / sulfuric acid / CH₂Cl₂ / 40 h / 20 °C

3: N,N-diisopropylethylamine / dioxane / 0.83 h / 20 °C

4: aq. hydrochloric acid / 2 h / pH 5

With hydrogenchloride; sulfuric acid; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1021/ja0580587