Technology Process of 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine1-oxide
There total 4 articles about 2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine1-oxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
phthalic anhydride; dihydrogen peroxide;
In
dichloromethane;
at 25 - 40 ℃;
for 18h;
Large scale;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: magnesium(II) sulfate / toluene / 18 h / 25 - 30 °C / Inert atmosphere; Large scale
1.2: 16 h / 0 - 25 °C / Inert atmosphere; Large scale
2.1: triethylamine / toluene / 16 h / 20 - 25 °C / Large scale
3.1: trichlorophosphate; N,N-dimethyl-formamide / 13 h / 5 - 105 °C / Large scale
4.1: phthalic anhydride; dihydrogen peroxide / dichloromethane / 18 h / 25 - 40 °C / Large scale
With
phthalic anhydride; dihydrogen peroxide; magnesium(II) sulfate; triethylamine; N,N-dimethyl-formamide; trichlorophosphate;
In
dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / toluene / 16 h / 20 - 25 °C / Large scale
2: trichlorophosphate; N,N-dimethyl-formamide / 13 h / 5 - 105 °C / Large scale
3: phthalic anhydride; dihydrogen peroxide / dichloromethane / 18 h / 25 - 40 °C / Large scale
With
phthalic anhydride; dihydrogen peroxide; triethylamine; N,N-dimethyl-formamide; trichlorophosphate;
In
dichloromethane; toluene;