(S)-1-(3-BROMOPHENYL)-2,2,2-TRIFLUOROETHANAMINE HYDROCHLORIDE

Base Information

• Chemical Name: (S)-1-(3-BROMOPHENYL)-2,2,2-TRIFLUOROETHANAMINE HYDROCHLORIDE
• CAS No.: 878408-46-9
• Molecular Formula: C₈H₇BrF₃N*ClH
• Molecular Weight: 290.51
• Mol file: 878408-46-9.mol

Synonyms:

Chemical Property of (S)-1-(3-BROMOPHENYL)-2,2,2-TRIFLUOROETHANAMINE HYDROCHLORIDE

Chemical Property:

• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

(S)-1-(3-Bromo-phenyl)-2,2,2-trifluoro-ethylaminehydrochloride 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(3-BROMOPHENYL)-2,2,2-TRIFLUOROETHANAMINE HYDROCHLORIDE

There total 6 articles about (S)-1-(3-BROMOPHENYL)-2,2,2-TRIFLUOROETHANAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2,2,2-Trifluoroacetophenone (434-45-7) → 1-(3-bromo-phenyl)-2,2,2-trifluoro-ethylamine; hydrochloride (878408-46-9,842169-71-5,842169-97-5)

Guidance literature:

2,2,2-Trifluoroacetophenone; With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at 20 ℃;

With sodium hydroxide; dimethylsulfide borane complex; In tetrahydrofuran; toluene; at 20 ℃;

With hydrogenchloride; In diethyl ether; toluene; at 20 ℃;

DOI:10.1021/ol047431x

Reference yield:

N-(trimethylsilyl)-1-(3-bromophenyl)-1-(2,2,2-trifluoromethyl)ketimine → (R)-2,2,2-trifluoro-1-(3-bromophenyl)ethylamine hydrochloride (878408-46-9,842169-71-5,842169-97-5) + (S)-2,2,2-trifluoro-1-(3-bromophenyl)ethylamine hydrochloride (878408-46-9,842169-71-5,842169-97-5)

Guidance literature:

N-(trimethylsilyl)-1-(3-bromophenyl)-1-(2,2,2-trifluoromethyl)ketimine; With methanol; at 20 ℃;

With (S)-B-butyl-diphenylpyrrolidino-oxazaborolidine; benzo[1,3,2]dioxaborole; In toluene; at -15 ℃; Title compound not separated from byproducts;

DOI:10.1021/ol047431x

Reference yield:

N-(trimethylsilyl)-1-(3-bromophenyl)-1-(2,2,2-trifluoromethyl)ketimine → (R)-2,2,2-trifluoro-1-(3-bromophenyl)ethylamine hydrochloride (878408-46-9,842169-71-5,842169-97-5) + (S)-2,2,2-trifluoro-1-(3-bromophenyl)ethylamine hydrochloride (878408-46-9,842169-71-5,842169-97-5)

Guidance literature:

N-(trimethylsilyl)-1-(3-bromophenyl)-1-(2,2,2-trifluoromethyl)ketimine; With methanol; at 20 ℃;

With (S)-B-butyl-diphenylpyrrolidino-oxazaborolidine; benzo[1,3,2]dioxaborole; In toluene; at -15 ℃; Title compound not separated from byproducts;

DOI:10.1021/ol047431x

upstream raw materials:

2,2,2-Trifluoroacetophenone

m-bromotrifluoroacetone

Refernces

• 1、 Gosselin, Francis,O'Shea, Paul D.,Roy, Stephanie,Reamer, Robert A.,Chen, Cheng-Yi,Volante, Ralph P.. "Unprecedented catalytic asymmetric reduction of N-H imines". . p. 355 - 358. Retrieved 2007/10/03.