3'-BROMO-2,2,2-TRIFLUOROACETOPHENONE

Base Information

• Chemical Name: 3'-BROMO-2,2,2-TRIFLUOROACETOPHENONE
• CAS No.: 655-26-5
• Molecular Formula: C8H4BrF3O
• Molecular Weight: 253.018
• Hs Code.: 2914790090
• Mol file: 655-26-5.mol

Synonyms:3'-BROMO-2,2,2-TRIFLUOROACETOPHENONE;3'-Bromo-2,2,2-trifluoroacetophenone 98%;1-(3-Bromophenyl)-2,2,2-trifluoroethan-1-one;1-(3-broMophenyl)-2;2-trifluoroethanone;3-Bromo-ααα-trifluoroacetophenone;3-Brom-α,α,α-trifluoracetophenon;3'-Bromo-2,2,2-trifluoroacetophenone >=97%

Chemical Property of 3'-BROMO-2,2,2-TRIFLUOROACETOPHENONE

Chemical Property:

• Vapor Pressure: 0.05mmHg at 25°C
• Refractive Index: n20/D 1.504
• Boiling Point: 235.626°C at 760 mmHg
• Flash Point: 96.304°C
• PSA: 17.07000
• Density: 1.637g/mLat 25℃
• LogP: 3.19410
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3''-Bromo-2,2,2-trifluoroacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 2329910
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3'-Bromo-2,2,2-trifluoroacetophenone is a useful research chemical.

Technology Process of 3'-BROMO-2,2,2-TRIFLUOROACETOPHENONE

There total 12 articles about 3'-BROMO-2,2,2-TRIFLUOROACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(±)-1-(3-bromophenyl)-2,2,2-trifluoroethanol (446-63-9,1188286-64-7) → m-bromotrifluoroacetone (655-26-5)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; for 22h; Reflux;

DOI:10.1016/j.tetlet.2013.06.045

Reference yield: 75.0%

ethyl trifluoroacetate, (383-63-1) + 1,3-dibromobenzene (108-36-1) → m-bromotrifluoroacetone (655-26-5)

Guidance literature:

1,3-dibromobenzene; With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

ethyl trifluoroacetate,; at -78 - 20 ℃; for 0.833333h;

DOI:10.1002/chem.201601540

Reference yield: 70.0%

trifluoromethan (75-46-7) + ethyl 3-bromobenzoate (24398-88-7) → m-bromotrifluoroacetone (655-26-5)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; sodium; diisopropylamine; isoprene; In n-heptane; at -60 ℃; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.201900250

upstream raw materials:

2,2,2-Trifluoroacetophenone

3-bromophenyl magnesium bromide

trifluoroacetic anhydride

(±)-1-(3-bromophenyl)-2,2,2-trifluoroethanol

Downstream raw materials:

2-(3-bromophenyl)-1,1,1-trifluoropropan-2-ol

3-(2,2,2-Trifluoro-1-hydroxy-1-methyl-ethyl)-benzonitrile

Toluene-4-sulfonic acid 1-(3-bromo-phenyl)-2,2,2-trifluoro-1-methyl-ethyl ester

3-Nitro-benzenesulfonic acid 1-(3-bromo-phenyl)-2,2,2-trifluoro-1-methyl-ethyl ester

Refernces

• 1、 Kani, Ryunosuke,Inuzuka, Toshiyasu,Kubota, Yasuhiro,Funabiki, Kazumasa. "One-Pot Successive Turbo Grignard Reactions for the Facile Synthesis of α-Aryl-α-Trifluoromethyl Alcohols". supporting information. p. 4487 - 4493. Retrieved 2020/06/01.
• 2、 Xu, Yimang,Yu, Shanshan,Chen, Qi,Chen, Xuemin,Li, Yinan,Yu, Xiaoqi,Pu, Lin. "Fluorescent Recognition of 1,2-Diamines by a 1,1′-Binaphthyl-Based Trifluoromethyl Ketone". . p. 12061 - 12067. Retrieved 2016/08/16.